Vanillin was obtained as a white solid (150 mg, 76% yield); m.p. 76-79 °C; ¹H NMR (400 MHz, CDCl₃) δ 9.82 (br s, 1H), 7.43-7.41 (m, 2H), 7.04 (d, J = 8.8 Hz, 1H), 6.30 (s, 1H), 3.96 (s, 3H).

In this experiment, we have demonstrated the synthesis of vanillin from isoeugenol using the ozonolysis reaction. Also, using an ozone generator while performing a low temperature reaction was shown.

Ozonolysis is a useful reaction to prepare aldehydes, ketones, and carboxylic acids from alkenes. It has been applied in natural product synthesis and industrial-scale preparation of pharmaceuticals. Artemisinin is a potent antimalarial agent and was one of the nat