JoVE Logo

Sign In

A subscription to JoVE is required to view this content.

Tumor Implantation and Injection of a Tumor Vaccine in a Mouse Model

-- views • 0:58 min

Transcript

Take an anesthetized and shaved mouse. Inject mouse skin cancer cells.

Due to the same genetic background, the host immune system does not reject the cancer cells, allowing them to grow into a tumor.

Measure the tumor dimensions periodically.

Take a tumor vaccine containing non-dividing skin cancer cells modified to secrete a cytokine that activates immune cells against the tumor.

Once the tumor grows to the desired size, inject the vaccine near the tumor.

The secreted cytokine binds to specific immune cells in the tumor region, triggering an immune signaling cascade.

This process recruits more immune cells to the tumor site.

Together, they target and destroy the cancer cells, suppressing the tumor growth.

article

01:46

Tumor Implantation and Injection of a Tumor Vaccine in a Mouse Model

Related Videos

104 Views

article

06:51

Manufacturing Chimeric Antigen Receptor (CAR) T Cells for Adoptive Immunotherapy

Related Videos

14.8K Views

article

15:24

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Related Videos

3.0K Views

article

08:43

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice

Related Videos

6.7K Views

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2025 MyJoVE Corporation. All rights reserved