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Modeling Neural Immune Signaling of Episodic and Chronic Migraine Using Spreading Depression In Vitro

DOI :

10.3791/2910-v

16:13 min

June 13th, 2011

June 13th, 2011

19,780 Views

1Department of Neurology and Committee on Neurobiology, The University of Chicago Medical Center, 2Department of Neurology, The University of Chicago Medical Center

Migraine and its transformation to chronic migraine are immense healthcare burdens in need of improved treatment options. We seek to define how neural immune signaling modulates the susceptibility to migraine, modeled in vitro using spreading depression in hippocampal slice cultures, as a means to develop novel therapeutic targets.

Tags

Neural Immune Signaling

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