JoVE Logo
Faculty Resource Center

Sign In

Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma

DOI :

10.3791/2941-v

12:03 min

July 25th, 2011

July 25th, 2011

18,511 Views

1Department of Neurobiology and Anatomy, Program in Cancer Cell Biology, Mary Babb Randolph Cancer Center, West Virginia University, 2Sensory Neuroscience Research Center, West Virginia University , 3Departments of Otolaryngology and Physiology, Center for Neuroscience, West Virginia University

A comprehensive overview of the techniques involved in generating a mouse model of oral cancer and quantitative monitoring of tumor invasion within the tongue through multi-photon microscopy of labeled cells is presented. This system can serve as a useful platform for the molecular assessment and drug efficacy of anti-invasive compounds.

Tags

Multi photon Imaging

-- Views

Related Videos

article

Combination Radiotherapy in an Orthotopic Mouse Brain Tumor Model

article

Modeling and Imaging 3-Dimensional Collective Cell Invasion

article

An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment

article

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

article

Using Quantitative Real-time PCR to Determine Donor Cell Engraftment in a Competitive Murine Bone Marrow Transplantation Model

article

An Orthotopic Glioblastoma Mouse Model Maintaining Brain Parenchymal Physical Constraints and Suitable for Intravital Two-photon Microscopy

article

An Alkali-burn Injury Model of Corneal Neovascularization in the Mouse

article

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

article

Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model

article

A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved