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Development of a Unilaterally-lesioned 6-OHDA Mouse Model of Parkinson's Disease

DOI :

10.3791/3234-v

February 14th, 2012

February 14th, 2012

50,255 Views

1Centre for Neurobiology of Stress, Dept Biological Sciences, University of Toronto at Scarborough

A protocol for performing unilateral 6-OHDA lesions of the medial forebrain bundle in mice is described. This method has a low mortality rate (13.3 %) with 89% of the surviving animals showing >95% loss of striatal dopamine and 90.63±-4.02 % ipsiversive rotational bias towards the side of the lesion.

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Unilaterally lesioned 6 OHDA Mouse Model

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