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Murine Model for Parkinson's Disease: from 6-OH Dopamine Lesion to Behavioral Test

DOI :

10.3791/1376-v

January 15th, 2010

January 15th, 2010

31,063 Views

1Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Brasil

Parkinson disease is caused by loss of dopaminergic innervation to the striatum, which can be experimentally induced by 6-OH-dopamine. We describe how to perform a stereotaxic lesion and to monitor apomorphine-induced rotational behavior in mice. This model is useful and reliable for testing new therapies for Parkinson disease.

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Murine Model

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