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New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals

DOI :

10.3791/50244-v

May 30th, 2013

May 30th, 2013

10,933 Views

1Ragon Institute of MGH, MIT, and Harvard, 2Division of Infectious Diseases, Massachusetts General Hospital

CD4+ Regulatory T cells are potent immune-modulators and serve important functions in immune homeostasis. The paucity of these cells in peripheral blood makes functional studies challenging, specifically in the context of HIV-1-infection. We here describe a method to isolate and expand functional CD4+ Tregs from peripheral blood from HIV-1-infected individuals.

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