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A Modified Heterotopic Swine Hind Limb Transplant Model for Translational Vascularized Composite Allotransplantation (VCA) Research

DOI :

10.3791/50475-v

October 14th, 2013

October 14th, 2013

12,300 Views

1Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine

Vascularized Composite Allotransplantations (VCA) have become a clinical reality. However, broad clinical application of VCA is limited by chronic multi-drug immunosuppression. The authors present a reliable and reproducible large animal model to translate novel immunomodulatory strategies that can minimize or potentially eliminate the need of immunosuppression in VCA.

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Modified Heterotopic Swine Hind Limb Transplant Model

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