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Heterotopic Mucosal Engrafting Procedure for Direct Drug Delivery to the Brain in Mice

DOI :

10.3791/51452-v

July 16th, 2014

July 16th, 2014

10,670 Views

1Department of Biomedical Engineering, Boston University, 2Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School

A mouse model of human endoscopic skull base reconstruction has been developed that creates a semipermeable interface between the brain and nose using nasal mucosal grafts. This method allows researchers to study delivery to the central nervous system of high molecular weight therapeutics which are otherwise excluded by the blood-brain barrier when administered systemically.

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Heterotopic Mucosal Engrafting Procedure

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