JoVE Logo
Faculty Resource Center

Sign In

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery

DOI :

10.3791/58485-v

November 14th, 2018

November 14th, 2018

19,207 Views

1Laboratory of Pharmaceutics, School of Pharmacy, Nihon University

Here, we describe two novel methods of stable intranasal administration under inhalation anesthesia with minimal physical stress for experimental animals. We also describe a method for quantitative evaluation of drug distribution levels in the brain via the nose-to-brain pathway using radiolabeled [14C]-inulin as a model substrate of water-soluble macromolecules.

Tags

Intranasal Administration

-- Views

Related Videos

article

A Novel Rescue Technique for Difficult Intubation and Difficult Ventilation

article

Use of Animal Model of Sepsis to Evaluate Novel Herbal Therapies

article

Intranasal Administration of CNS Therapeutics to Awake Mice

article

Heterotopic Mucosal Engrafting Procedure for Direct Drug Delivery to the Brain in Mice

article

Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium

article

Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model

article

Optimized LC-MS/MS Method for the High-throughput Analysis of Clinical Samples of Ivacaftor, Its Major Metabolites, and Lumacaftor in Biological Fluids of Cystic Fibrosis Patients

article

Improved Method for the Establishment of an In Vitro Blood-Brain Barrier Model Based on Porcine Brain Endothelial Cells

article

CO2-Lasertonsillotomy Under Local Anesthesia in Adults

article

Intratracheal Administration of Dry Powder Formulation in Mice

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved