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Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery

DOI :

10.3791/58485-v

November 14th, 2018

November 14th, 2018

18,714 Views

1Laboratory of Pharmaceutics, School of Pharmacy, Nihon University

Here, we describe two novel methods of stable intranasal administration under inhalation anesthesia with minimal physical stress for experimental animals. We also describe a method for quantitative evaluation of drug distribution levels in the brain via the nose-to-brain pathway using radiolabeled [14C]-inulin as a model substrate of water-soluble macromolecules.

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