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Visual Evoked Potential Recording in a Rat Model of Experimental Optic Nerve Demyelination

DOI :

10.3791/52934-v

July 29th, 2015

July 29th, 2015

11,861 Views

1Department of Ophthalmology, Australian School of Advanced Medicine, Macquarie University, 2Save Sight Institute, The University of Sydney

Focal demyelination is induced in the optic nerve using lysolecithin microinjection. Visual evoked potentials are recorded via skull electrodes implanted over the visual cortex to examine the signal conduction along the visual pathway in vivo. This protocol details the surgical procedures underlying electrode implantation and optic nerve microinjection.

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Visual Evoked Potential

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