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Development of an Ethanol-induced Fibrotic Liver Model in Zebrafish to Study Progenitor Cell-mediated Hepatocyte Regeneration

DOI :

10.3791/54002-v

May 13th, 2016

May 13th, 2016

8,910 Views

1School of Biology, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology

Sustained fibrosis with deposition of excessive extracellular matrix proteins leads to cirrhosis. Alcohol abuse is one of the main causes of severe liver disease. We established an ethanol-induced zebrafish fibrotic liver model to study the mechanisms and strategies of promoting hepatocyte regeneration upon alcohol-induced injury.

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