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Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

DOI :

10.3791/54242-v

June 7th, 2017

June 7th, 2017

8,039 Views

1Department of Medicine, Icahn School of Medicine at Mount Sinai, 2Immunología de Trasplantes, Centro Nacional de Microbiología, Instituto de Salud Carlos III

Macrophages are plastic cells of the hematopoietic system that have a crucial role in protective immunity and homeostasis. In this report, we describe optimized in vitro techniques to phenotypically and functionally characterize graft-infiltrating regulatory macrophages that accumulate in the transplanted organ under tolerogenic conditions.

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