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The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

DOI :

10.3791/54445-v

October 7th, 2016

October 7th, 2016

10,817 Views

1Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano

We present a protocol for the synthesis of RGD-functionalized hydrogels as devices for cell and drug delivery. The procedure involves copper catalyzed alkyne-azide cycloaddition (CuAAC) between alkyne-modified polyacrylic acid (PAA) and a RGD-azide derivative. The hydrogels are formed using microwave-assisted polycondensation and their physicochemical properties are investigated.

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Hydrogel Synthesis

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