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Automated Acoustic Dispensing for the Serial Dilution of Peptide Agonists in Potency Determination Assays

DOI :

10.3791/54542-v

November 10th, 2016

November 10th, 2016

7,443 Views

1Cardiovascular & Metabolic Disease, MedImmune, 2Lab Automation and Support, MedImmune

Peptide adsorption to plasticware during traditional tip-based serial dilutions can significantly impact potency determination and confound the understanding of structure-activity relationships used for lead identification and lead optimization phases of drug discovery. Here methods for automated acoustic non-contact serial dilution of peptide samples are described.

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