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Method of Direct Segmental Intra-hepatic Delivery Using a Rat Liver Hilar Clamp Model

DOI :

10.3791/54729-v

9:22 min

April 2nd, 2017

April 2nd, 2017

13,631 Views

1Collaboration for Organ Perfusion, Protection, Engineering and Regeneration (COPPER) Lab, Division of Transplant, Department of Surgery, Comprehensive Transplant Center, The Ohio State University Wexner Medical Center

A unique rat liver hilar clamp model was developed for studying the impact of pharmacologic molecules in ameliorating ischemia-reperfusion injury. This model includes direct cannulation of the portal supply to the ischemic liver segment via a branch of the portal vein, allowing for direct hepatic delivery.

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Keywords Rat Liver Hilar Clamp Model

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