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A Mouse Model of Fatigue Induced by Peripheral Irradiation

DOI :

10.3791/55145-v

March 17th, 2017

March 17th, 2017

7,632 Views

1Symptom Biology Unit, National Institute of Nursing Research, National Institutes of Health, 2Murine Phenotyping Core, National Heart, Lung, and Blood Institute, National Institutes of Health

We describe a method using targeted peripheral irradiation to induce fatigue-like behavior in mice. The selected non-lethal irradiation dose leads to a week-long reduction in voluntary wheel-running activity.

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Keywords Mouse Model

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