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Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

DOI :

10.3791/55773-v

June 16th, 2017

June 16th, 2017

9,512 Views

1Department of Medical Genetics, Institute of Biomedicine, Gothenburg University, 2Department of Clinical Chemistry and Transfusion Medicine, Institute of Biomedicine, Gothenburg University

This work describes an optimized methyl-CpG-binding domain (MBD) sequencing protocol and a computational pipeline to identify differentially methylated CpG-rich regions in chronic lymphocytic leukemia (CLL) patients.

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