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Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

DOI :

10.3791/55967-v

August 11th, 2017

August 11th, 2017

8,632 Views

1Institute of Molecular Oncology, Showa University, 2Center for Biotechnology, Showa University

An in vitro method for establishing dual resistance to an EGFR-TKI and a MET-TKI in cancer cells is described. This method is useful for developing treatments for patients with EGFR-mutations, who exhibit disease progression despite EGFR-TKI treatment with MET-amplification. It can also be modified for inhibitors targeting other molecules.

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Keywords Lung Adenocarcinoma

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