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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

DOI :

10.3791/56023-v

March 30th, 2018

March 30th, 2018

10,877 Views

1Department of Pathology and Immunology, University of Geneva, 2Hematology Service, University Hospital, Geneva

Mantle cell lymphoma (MCL) is a difficult to treat B cell disorder and it is equally difficult to establish a xenograft mouse model of primary MCL to study and develop therapeutics. Here, we describe the successful establishment of MCL xenografts in mice to help understand its underlying biology.

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Xenograft Mouse Model

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