Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

10.8K Views

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08:57 min

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October 5th, 2017

DOI :

10.3791/56159-v

October 5th, 2017

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Rui Xue Zhang¹, Tian Zhang¹, King Chen¹, Ji Cheng¹, Paris Lai¹, Andrew M. Rauth², K. Sandy Pang¹, Xiao Yu Wu¹

¹Department of Pharmaceutical Sciences, University of Toronto, ²Departments of Medical Biophysics and Radiation Oncology, University of Toronto, Ontario Cancer Institute, University Health Network

Summary

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Simultaneous Quantitation

Sample Preparation

Tissue Homogenization

Extraction

Internal Standard

Chapters in this video

0:05

Title

1:20

Biological Sample Preparation

3:35

HPLC Instrumentation and Operation Parameters

4:50

Analysis of Samples

5:46

Results: Drug Combination Delivery of Doxorubicin and Mitomycin C in Nanoparticles

7:43

Conclusion

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