JoVE Logo
Faculty Resource Center

Sign In

Microfluidic Device for Recreating a Tumor Microenvironment in Vitro

DOI :

10.3791/2425-v

November 20th, 2011

November 20th, 2011

11,324 Views

1Department of Chemical Engineering, University Of Massachusetts Amherst

We present the procedure for fabrication and operation of a microfluidic device that recreates heterogeneous tumor microenvironments in vitro. The variability in apoptosis within tumor tissue was quantified using fluorescent stains and the effective diffusion coefficient of the chemotherapeutic drug doxorubicin into tumor tissue was evaluated.

Tags

Microfluidic Device

-- Views

Related Videos

article

A Microfluidic Device for Studying Multiple Distinct Strains

article

Systematic Analysis of In Vitro Cell Rolling Using a Multi-well Plate Microfluidic System

article

Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion

article

Protocol for Biofilm Streamer Formation in a Microfluidic Device with Micro-pillars

article

Use of a High-throughput In Vitro Microfluidic System to Develop Oral Multi-species Biofilms

article

Analyzing Mixing Inhomogeneity in a Microfluidic Device by Microscale Schlieren Technique

article

Eye Irritation Test (EIT) for Hazard Identification of Eye Irritating Chemicals using Reconstructed Human Cornea-like Epithelial (RhCE) Tissue Model

article

Fully Automated Centrifugal Microfluidic Device for Ultrasensitive Protein Detection from Whole Blood

article

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

article

Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved