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Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models

DOI :

10.3791/57088-v

10:04 min

March 13th, 2018

March 13th, 2018

11,480 Views

1Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London

We describe a protocol for preclinical in vivo tracking of cancer metastasis. It is based on a radionuclide-fluorescence reporter combining the sodium iodide symporter, detected by non-invasive [18F]tetrafluoroborate-PET, and a fluorescent protein for streamlined ex vivo confirmation. The method is applicable for preclinical in vivo cell tracking beyond tumor biology.

Tags

Radionuclide fluorescence

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