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Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis

DOI :

10.3791/57398-v

March 8th, 2018

March 8th, 2018

8,648 Views

1Department of Clinical Neuroscience, Section of Eye and Vision, St Erik Eye Hospital, Karolinska Institutet

Iris neovascularization, a common complication of ischemic retinal disease, may lead to sight-threatening neovascular glaucoma. Here, we describe a murine protocol for inducing experimental iris neovascularization that may be used for noninvasive evaluation of angiogenesis-modulating substances.

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Keywords Iris Neovascularization

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