JoVE Logo
Faculty Resource Center

Sign In

Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening

DOI :

10.3791/57476-v

September 5th, 2018

September 5th, 2018

8,313 Views

1Oncology Drug Discovery: Molecular Pharmacology, Novartis Institutes for Biomedical Research, 2Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research

Across a wide variety of disease indications, more physiologically relevant models are being developed and implemented into drug discovery programs. The new model system described here demonstrates how three-dimensional tumor spheroids can be cultured and screened in a high-throughput 1536-well plate-based system to search for new oncology drugs.

Tags

High throughput

-- Views

Related Videos

article

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

article

A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants

article

Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography

article

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

article

Fully Human Tumor-based Matrix in Three-dimensional Spheroid Invasion Assay

article

Physiologic Patient Derived 3D Spheroids for Anti-neoplastic Drug Screening to Target Cancer Stem Cells

article

Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids

article

Drug Screening of Primary Patient Derived Tumor Xenografts in Zebrafish

article

A Three-dimensional Model of Spheroids to Study Colon Cancer Stem Cells

article

High-Throughput In Vitro Assay using Patient-Derived Tumor Organoids

JoVE Logo

Privacy

Terms of Use

Policies

Research

Education

ABOUT JoVE

Copyright © 2024 MyJoVE Corporation. All rights reserved