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Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening

DOI :

10.3791/57476-v

September 5th, 2018

September 5th, 2018

8,312 Views

1Oncology Drug Discovery: Molecular Pharmacology, Novartis Institutes for Biomedical Research, 2Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research

Across a wide variety of disease indications, more physiologically relevant models are being developed and implemented into drug discovery programs. The new model system described here demonstrates how three-dimensional tumor spheroids can be cultured and screened in a high-throughput 1536-well plate-based system to search for new oncology drugs.

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High throughput

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