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Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting

DOI :

10.3791/58480-v

October 26th, 2018

October 26th, 2018

8,104 Views

1Center of Biomedical Education and Research, University Witten/Herdecke

The protocol described here enables researchers to specifically modify adenovirus capsids at selected sites by simple chemistry. Shielded adenovirus vectors particles and retargeted gene transfer vectors can be generated, and vector host interactions can be studied.

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