Intramyocardial Transplantation of MSC-Loading Injectable Hydrogels after Myocardial Infarction in a Murine Model

4.3K Views

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09:19 min

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September 20th, 2020

DOI :

10.3791/61752-v

September 20th, 2020

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Chan Woo Kim¹^,², Chan Joon Kim¹^,³, Eun-Hye Park¹^,², Eunmi Lee¹^,², Eunhwa Seong¹^,², Kiyuk Chang¹^,²

¹Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea, ²Division of Cardiology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, ³Division of Cardiology, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea

Summary

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Intramyocardial Transplantation

MSC loading Hydrogels

Myocardial Infarction

Stem Cells

Cardiac Therapy

Tissue Repair

Regenerative Medicine

Cell Retention

Survival Of Transplanted Cells

Injectable Hydrogels

Culture Mesenchymal Stem Cells

In situ Cross linking

Growth Factors

Genetic Materials

Vascular Tissue Engineering

Chapters in this video

0:05

Introduction

1:49

Preparation of MSCs and Injectable Gelatin Hydrogels

3:38

In Situ MSC-loading and Three-dimensional in Vitro Culture

4:29

Induction of Myocardial Infarction in Mice

5:44

Intramyocardial Transplantation of MSC-loading GH Hydrogels

6:37

Results: Improving Stem Cell Retention and Engraftment with Injectable Hydrogels

8:31

Conclusion

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