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Developing 3D Organized Human Cardiac Tissue within a Microfluidic Platform

DOI :

10.3791/62539-v

June 15th, 2021

June 15th, 2021

4,471 Views

1School of Biological and Health Systems Engineering, Arizona State University, 2Biodesign Virginia G. Piper Center for Personalized Diagnostics, Arizona State University

The goal of this protocol is to explain and demonstrate the development of a three-dimensional (3D) microfluidic model of highly aligned human cardiac tissue, composed of stem cell-derived cardiomyocytes co-cultured with cardiac fibroblasts (CFs) within a biomimetic, collagen-based hydrogel, for applications in cardiac tissue engineering, drug screening, and disease modeling.

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