Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

2.9K Views

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07:13 min

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October 20th, 2021

DOI :

10.3791/63085-v

October 20th, 2021

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Hongkai Wang¹^,², Dom D’Andrea¹, Yeon Sik Choi³^,⁴, Yasmine Bouricha¹, Grace Wickerson³^,⁴, Hak-Young Ahn³, Hexia Guo³^,⁴, Yonggang Huang³^,⁴^,⁵^,⁶, Milap S. Sandhu⁷, Sumanas W. Jordan⁸, John A. Rogers³^,⁴^,⁶^,⁹^,¹⁰^,¹¹^,¹², Colin K. Franz¹^,³^,¹³

¹Laboratory of Regenerative Rehabilitation, Shirley Ryan AbilityLab, Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, ²Northwestern University Interdepartmental Neuroscience Program, ³Center for Bio-integrated Electronics, Querrey Simpson Institute for Bioelectronics, Northwestern University, ⁴Department of Materials Science and Engineering, Northwestern University, ⁵Department of Civil and Environmental Engineering, Northwestern University, ⁶Department of Mechanical Engineering, Northwestern University, ⁷Arms and Hands Lab, Shirley Ryan AbilityLab, Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg School of Medicine, ⁸Division of Plastic and Reconstructive Surgery, Biologics, Shirley Ryan AbilityLab, Northwestern University, ⁹Department of Biomedical Engineering, Northwestern University, ¹⁰Department of Neurological Surgery, Northwestern University, ¹¹Department of Chemistry, Northwestern University, ¹²Department of Electrical and Computer Engineering, Northwestern University, ¹³The Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine

Summary

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Peripheral Nerve Injury

Electrical Stimulation

Nerve Regeneration

Wireless Systems

Battery free Devices

Nerve Interfacing

Surgical Procedure

Anesthetic Monitoring

Sciatic Nerve Isolation

Continuous Stimulation

Therapeutic Potential

Chapters in this video

0:00

Introduction

0:58

Surgical Procedure for Implantation of a Wireless, Battery‐Free Peripheral Nerve Interface on the Right Sciatic Nerve of the Rat for Electrical Stimulation

3:07

Surgical Procedure for the Implantation of Wireless Stimulators on the Left Phrenic Nerve of the Rat

4:46

Wireless Delivery of Therapeutic Electrical Stimulation

5:29

Results: Nerve Conduction Studies, EMG Recording, and Nerve Regeneration in the Sciatic Nerve Injury Model

6:42

Conclusion

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