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JoVE Journal

Medicine

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Transdermal Measurement of Glomerular Filtration Rate in Mechanically Ventilated Piglets

2.1K Views

07:41 min

September 13th, 2022

September 13th, 2022

2,085 Views

0:05

Introduction

1:13

Experiment Group: Cecal Ligation and Perforation (CLP)

2:35

Transdermal GFR Device Setup

3:49

FITC-Sinistrin Preparation, Injection, and Transdermal GFR Recording

4:43

GFR Measurement

5:47

Results: Analysis of GFR Using Transdermal GFR Device

7:02

Conclusion

Glomerular filtration rate (GFR) is the ideal marker for assessing kidney function. However, the standard measurement method using inulin injection with serial blood and urine analysis is impractical. This article delineates a practical method to measure GFR transdermally in piglets.

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