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Measurement of the Pressure-volume Curve in Mouse Lungs

DOI :

10.3791/52376-v

January 27th, 2015

January 27th, 2015

18,195 Views

1Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University

Here we present a protocol to simply and reliably measure the lung pressure-volume curve in mice, showing that it is sufficiently sensitive to detect phenotypic parenchymal changes in two common lung pathologies, pulmonary fibrosis and emphysema. This metric provides a means to quantify the lung’s structural changes with developing pathology.

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Pressure volume Curve

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