1 This article evaluated the feasibility, target2 and the mechanism of ShiDuGao in treating anus eczema. 3 Network pharmacology and GEO database analysis 4 confirms the multi-target nature of SDG 5 in treating anal eczema, 6 specifically by modulating TNF and APK 14, 7 and the CASP3, 8 which are crucial hub targets in the TNF 9 and MAPK signaling pathways. 10 These fundings provide a clear direction 11 for further investigation into SDG's 12 therapeutic mechanism for anal eczema, 13 while highlighting its potential 14 as an effective treatment approach 15 for this debilitating condition.
16 Mechanism research is acknowledged17 as the most intricate aspect 18 of herbal prescription investigation. 19 Network pharmacology currently permits diverse aspect 20 of the pharmacentrical field, 21 making a paradigm shift from conventional 22 to contemporary biomedicine, 23 and refining traditional Chinese medicine development. 24 This research combined network pharmacology 25 with GEO dataset to discern to topical drug mechanisms.
26 In this study, the pure data generation method27 was used to maximize data utilization 28 by combining modified disease, 29 especially for some diseases that are difficult 30 to build animal models for. 31 The online data are used primarily to predict 32 and verify diseases and drug targets, 33 so as to gather research direction 34 and lay a good foundation 35 for subsequent experimental verification.
