Martin Picard

Functional properties of sarcoplasmic reticulum Ca(2+)-ATPase after proteolytic cleavage at Leu119-Lys120, close to the A-domain.

Involvement of the L6-7 loop in SERCA1a Ca2+-ATPase activation by Ca2+ (or Sr2+) and ATP.

Stabilization of membranes upon interaction of amphipathic polymers with membrane proteins.

The average conformation at micromolar [Ca2+] of Ca2+-atpase with bound nucleotide differs from that adopted with the transition state analog ADP.AlFx or with AMPPCP under crystallization conditions at millimolar [Ca2+].

Effects of inhibitors on luminal opening of Ca2+ binding sites in an E2P-like complex of sarcoplasmic reticulum Ca22+-ATPase with Be22+-fluoride.

Protective and inhibitory effects of various types of amphipols on the Ca2+-ATPase from sarcoplasmic reticulum: a comparative study.

Conformational changes in sarcoplasmic reticulum Ca(2+)-ATPase mutants: effect of mutations either at Ca(2+)-binding site II or at tryptophan 552 in the cytosolic domain.

Ca2+ versus Mg2+ coordination at the nucleotide-binding site of the sarcoplasmic reticulum Ca2+-ATPase.

Inhibitors bound to Ca(2+)-free sarcoplasmic reticulum Ca(2+)-ATPase lock its transmembrane region but not necessarily its cytosolic region, revealing the flexibility of the loops connecting transmembrane and cytosolic domains.

The structural basis of calcium transport by the calcium pump.

Resistance to Ca2+-induced opening of the permeability transition pore differs in mitochondria from glycolytic and oxidative muscles.

The mitochondrial phenotype of peripheral muscle in chronic obstructive pulmonary disease: disuse or dysfunction?

Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme.

Structural and dynamical insights into the opening mechanism of P. aeruginosa OprM channel.

Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma.

Targeting integrins in malignant glioma.

Mitochondrial functional impairment with aging is exaggerated in isolated mitochondria compared to permeabilized myofibers.

The need for a trans-disciplinary, global health framework.

Mitochondrial structure and function are disrupted by standard isolation methods.

Mitochondria: isolation, structure and function.

A transdisciplinary perspective of chronic stress in relation to psychopathology throughout life span development.

Alterations in intrinsic mitochondrial function with aging are fiber type-specific and do not explain differential atrophy between muscles.

Pathways to aging: the mitochondrion at the intersection of biological and psychosocial sciences.

Mitochondrial functional specialization in glycolytic and oxidative muscle fibers: tailoring the organelle for optimal function.

Activity monitoring of functional OprM using a biomimetic microfluidic device.

Mitochondria: starving to reach quorum?: Insight into the physiological purpose of mitochondrial fusion.

Photo-induced proton gradients for the in vitro investigation of bacterial efflux pumps.

Stoichiometry of the MexA-OprM binding, as investigated by blue native gel electrophoresis.

Integrins as therapeutic targets.

Mitochondrial function in permeabilized cardiomyocytes is largely preserved in the senescent rat myocardium.

Mitochondrial dysfunction and lipid accumulation in the human diaphragm during mechanical ventilation.

Mitochondrial morphology, topology, and membrane interactions in skeletal muscle: a quantitative three-dimensional electron microscopy study.

Mitochondrial morphology transitions and functions: implications for retrograde signaling?

Linking the metabolic state and mitochondrial DNA in chronic disease, health, and aging.

Hoechst likes to play hide and seek...use it with caution!

Acute exercise remodels mitochondrial membrane interactions in mouse skeletal muscle.

Allostatic load as a tool for monitoring physiological dysregulations and comorbidities in patients with severe mental illnesses.

Mitochondria impact brain function and cognition.

Cilengitide treatment of newly diagnosed glioblastoma patients does not alter patterns of progression.

Role of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in denervation-induced atrophy in aged muscle: facts and hypotheses.