Department of General,
Visceral,
Transplantation,
Vascular and Paediatric Surgery,
Department of Surgery I,
Department of General, Visceral, Transplantation, Vascular and Paediatric Surgery, Department of Surgery I
Nicolas Schlegel has not added Biography.
If you are Nicolas Schlegel and would like to personalize this page please email our Author Liaison for assistance.
Lipopolysaccharide-induced endothelial barrier breakdown is cyclic adenosine monophosphate dependent in vivo and in vitro.
Critical care medicine May, 2009 | Pubmed ID: 19325485
Impaired integrin-mediated adhesion contributes to reduced barrier properties in VASP-deficient microvascular endothelium.
Journal of cellular physiology Aug, 2009 | Pubmed ID: 19347869
Endothelial barrier stabilization by a cyclic tandem peptide targeting VE-cadherin transinteraction in vitro and in vivo.
Journal of cell science May, 2009 | Pubmed ID: 19420236
Impaired cAMP and Rac 1 signaling contribute to TNF-alpha-induced endothelial barrier breakdown in microvascular endothelium.
Microcirculation (New York, N.Y. : 1994) Aug, 2009 | Pubmed ID: 19504398
The impact of crystalloid and colloid infusion on the kidney in rodent sepsis.
Intensive care medicine Mar, 2010 | Pubmed ID: 19890625
Desmoglein 2-mediated adhesion is required for intestinal epithelial barrier integrity.
American journal of physiology. Gastrointestinal and liver physiology May, 2010 | Pubmed ID: 20224006
Differential role of Rho GTPases in intestinal epithelial barrier regulation in vitro.
Journal of cellular physiology May, 2011 | Pubmed ID: 20945370
Pulmonary effects of positive end-expiratory pressure and fluid therapy in experimental lung injury.
Experimental lung research Feb, 2011 | Pubmed ID: 21077780
Atrial natriuretic peptide enhances microvascular albumin permeability by the caveolae-mediated transcellular pathway.
Cardiovascular research Jan, 2012 | Pubmed ID: 22025581
Phosphodiesterase-4 inhibition as a therapeutic approach to treat capillary leakage in systemic inflammation.
The Journal of physiology Jun, 2012 | Pubmed ID: 22495586
Role of NF-κB activation in LPS-induced endothelial barrier breakdown.
Histochemistry and cell biology Oct, 2012 | Pubmed ID: 22718247
Effects of crystalloids and colloids on liver and intestine microcirculation and function in cecal ligation and puncture induced septic rodents.
BMC gastroenterology Dec, 2012 | Pubmed ID: 23245375
Phosphodiesterase 4 inhibition dose dependently stabilizes microvascular barrier functions and microcirculation in a rodent model of polymicrobial sepsis.
Shock (Augusta, Ga.) Jun, 2014 | Pubmed ID: 24569506
[Is a different view on the pathophysiology of sepsis the key for novel therapeutic options?].
Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen Aug, 2014 | Pubmed ID: 25103839
E7080 (lenvatinib), a multi-targeted tyrosine kinase inhibitor, demonstrates antitumor activities against colorectal cancer xenografts.
Neoplasia (New York, N.Y.) Nov, 2014 | Pubmed ID: 25425971
Phosphodiesterase-4 inhibition with rolipram attenuates hepatocellular injury in hyperinflammation in vivo and in vitro without influencing inflammation and HO-1 expression.
Journal of pharmacology & pharmacotherapeutics Jan-Mar, 2015 | Pubmed ID: 25709347
Sphincter-sparing intersphincteric rectal resection as an alternative to proctectomy in long-standing fistulizing and stenotic Crohn's proctitis?
International journal of colorectal disease May, 2015 | Pubmed ID: 25847822
Soluble VE-cadherin is involved in endothelial barrier breakdown in systemic inflammation and sepsis.
Cardiovascular research Jul, 2015 | Pubmed ID: 25975259
Sepsis-induced acute kidney injury by standardized colon ascendens stent peritonitis in rats - a simple, reproducible animal model.
Intensive care medicine experimental Dec, 2014 | Pubmed ID: 26266931
Glial cell line-derived neurotrophic factor promotes barrier maturation and wound healing in intestinal epithelial cells in vitro.
American journal of physiology. Gastrointestinal and liver physiology Oct, 2015 | Pubmed ID: 26294673
Balanced Hydroxyethylstarch (HES 130/0.4) Impairs Kidney Function In-Vivo without Inflammation.
PloS one , 2015 | Pubmed ID: 26340751
The glial cell-line derived neurotrophic factor: a novel regulator of intestinal barrier function in health and disease.
American journal of physiology. Gastrointestinal and liver physiology 06, 2016 | Pubmed ID: 27151942
[Updated definition of sepsis : Implications for diagnostics and therapy principles].
Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen Jan, 2017 | Pubmed ID: 27975124
Sphingosine-1-Phosphate Receptor-1 Agonist Sew2871 Causes Severe Cardiac Side Effects and Does Not Improve Microvascular Barrier Breakdown in Sepsis.
Shock (Augusta, Ga.) Jan, 2018 | Pubmed ID: 28538086
[Expectations of visceral surgeons from the results of clinical autopsies].
Der Pathologe Sep, 2017 | Pubmed ID: 28660345
Dsg2 via Src-mediated transactivation shapes EGFR signaling towards cell adhesion.
Cellular and molecular life sciences : CMLS Nov, 2018 | Pubmed ID: 29980799
Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury.
Mucosal immunology 11, 2018 | Pubmed ID: 30115995
Ureaplasma species modulate cell adhesion molecules and growth factors in human brain microvascular endothelial cells.
Cytokine 09, 2019 | Pubmed ID: 31158700
Correction to: Dsg2 via Src-mediated transactivation shapes EGFR signaling towards cell adhesion.
Cellular and molecular life sciences : CMLS 09, 2019 | Pubmed ID: 31292664
Prognostic Relevance of Steroid Sulfation in Adrenocortical Carcinoma Revealed by Molecular Phenotyping Using High-Resolution Mass Spectrometry Imaging.
Clinical chemistry 10, 2019 | Pubmed ID: 31492715
Mortality and Complications Following Visceral Surgery: A Nationwide Analysis Based on the Diagnostic Categories Used in German Hospital Invoicing Data.
Deutsches Arzteblatt international 11, 2019 | Pubmed ID: 31774053
Serum-derived factors of breast cancer patients with brain metastases alter permeability of a human blood-brain barrier model.
Fluids and barriers of the CNS Apr, 2020 | Pubmed ID: 32321535
Clinical Presentation, Treatment, and Outcome of Parathyroid Carcinoma: Results of the NEKAR Retrospective International Multicenter Study.
Annals of surgery 02, 2022 | Pubmed ID: 32649472
Case Report: Abdominal Lymph Node Metastases of Parathyroid Carcinoma: Diagnostic Workup, Molecular Diagnosis, and Clinical Management.
Frontiers in endocrinology , 2021 | Pubmed ID: 33833736
Prognostic impact of additive chemotherapy after curative resection of metachronous colorectal liver metastasis: a single-centre retrospective study.
BMC cancer May, 2021 | Pubmed ID: 33941104
Evaluation of diagnostic efficacy for localization of parathyroid adenoma in patients with primary hyperparathyroidism undergoing repeat surgery.
Langenbeck's archives of surgery Aug, 2021 | Pubmed ID: 33993327
G6b-B regulates an essential step in megakaryocyte maturation.
Blood advances Feb, 2022 | Pubmed ID: 35134123
Natalie Burkard1,
Wolfgang Baar2,3,
Sven Flemming1,
Nicolas Schlegel1,
Jakob Wollborn2,3,
Reinhard Schneider4,
Robert W Brock5,
Christian Wunder6,
Martin Alexander Schick2,3
1Department of General, Visceral, Transplantation, Vascular and Paediatric Surgery, Department of Surgery I, University of Würzburg,
2Department of Anesthesiology and Critical Care, Medical Center-University of Freiburg,
3Faculty of Medicine, University of Freiburg,
4Department of Internal Medicine I, Division of Nephrology, University of Würzburg,
5Department of Physiology and Pharmacology, West Virginia University School of Medicine, Robert C. Byrd Health Science Center,
6Department of Anesthesiology and Intensive Care Medicine, Robert-Bosch-Krankenhaus
ABOUT JoVE
Copyright © 2024 MyJoVE Corporation. All rights reserved