Wuqiang Zhu
Department of Biomedical Engineering,
School of Medicine,
School of Engineering,
Department of Biomedical Engineering, School of Medicine, School of Engineering
University of Alabama at Birmingham
Wuqiang Zhu is an Assistant Professor in the Department of Biomedical Engineering, The University of Alabama at Birmingham. He received his M.D. degree from Hubei Medical University, and a Ph.D. degree from the Tongji Medical College of Huazhong University of Science and Technology. After several years of clinic training in China, Dr. Zhu came to the United States and started his 2nd Ph.D. training in the laboratory of Dr. Loren Field (Indiana University). Upon the completion of his Ph.D., he received the postdoc training in the laboratories of Dr. Gangjian Qin (Northwestern University), Dr. Loren Field (Indiana University), Dr. Jop van Berlo (University of Minnesota), and Dr. Jianyi “Jay” Zhang (University of Minnesota). Dr. Zhu started his first faculty position in the Department of Biomedical Engineering, The University of Alabama at Birmingham in 2015. The research in his laboratory is mainly focused on myocardial regeneration, stem cells, and cardiac tissue engineering. His laboratory is currently funded by National Institutes of Health and American Heart Association.
Overexpression of bone morphogenetic protein 10 in myocardium disrupts cardiac postnatal hypertrophic growth.
The Journal of biological chemistry Sep, 2006 | Pubmed ID: 16798733
Expression of a mutant p193/CUL7 molecule confers resistance to MG132- and etoposide-induced apoptosis independent of p53 or Parc binding.
Biochimica et biophysica acta Mar, 2007 | Pubmed ID: 17229476
Cardiac restricted overexpression of kinase-dead mammalian target of rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac function.
The Journal of biological chemistry May, 2008 | Pubmed ID: 18326485
The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation.
Molecular cell May, 2008 | Pubmed ID: 18498745
A mouse model for juvenile doxorubicin-induced cardiac dysfunction.
Pediatric research Nov, 2008 | Pubmed ID: 18614963
Smad7 is required for the development and function of the heart.
The Journal of biological chemistry Jan, 2009 | Pubmed ID: 18952608
Acute doxorubicin cardiotoxicity is associated with p53-induced inhibition of the mammalian target of rapamycin pathway.
Circulation Jan, 2009 | Pubmed ID: 19103993
Cell-cycle-based strategies to drive myocardial repair.
Pediatric cardiology Jul, 2009 | Pubmed ID: 19340478
Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression.
Circulation research May, 2009 | Pubmed ID: 19407239
Differential cardiac remodeling in preload versus afterload.
Circulation Sep, 2010 | Pubmed ID: 20733099
Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis.
Development (Cambridge, England) Jan, 2011 | Pubmed ID: 21177343
FKBP12 is a critical regulator of the heart rhythm and the cardiac voltage-gated sodium current in mice.
Circulation research Apr, 2011 | Pubmed ID: 21372286
Granulocyte colony-stimulating factor treatment plus dipeptidylpeptidase-IV inhibition augments myocardial regeneration in mice expressing cyclin D2 in adult cardiomyocytes.
European heart journal Jan, 2012 | Pubmed ID: 21849352
Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy.
Human molecular genetics Dec, 2011 | Pubmed ID: 21880664
Tbx20 transcription factor is a downstream mediator for bone morphogenetic protein-10 in regulating cardiac ventricular wall development and function.
The Journal of biological chemistry Oct, 2011 | Pubmed ID: 21890625
Triggered firing and atrial fibrillation in transgenic mice with selective atrial fibrosis induced by overexpression of TGF-β1.
Circulation journal : official journal of the Japanese Circulation Society , 2012 | Pubmed ID: 22447020
Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity.
Development (Cambridge, England) May, 2013 | Pubmed ID: 23571217
P53 inhibition exacerbates late-stage anthracycline cardiotoxicity.
Cardiovascular research Jul, 2014 | Pubmed ID: 24812279
Critical Roles of STAT3 in β-Adrenergic Functions in the Heart.
Circulation Jan, 2016 | Pubmed ID: 26628621
31P NMR 2D Mapping of Creatine Kinase Forward Flux Rate in Hearts with Postinfarction Left Ventricular Remodeling in Response to Cell Therapy.
PloS one , 2016 | Pubmed ID: 27606901
Biomarkers for monitoring chemotherapy-induced cardiotoxicity.
Critical reviews in clinical laboratory sciences Dec, 2016 | Pubmed ID: 28013560
Meeting Report for the 2017 National Institutes of Health National Heart, Lung, and Blood Institute Progenitor Cell Biology Consortium: Cardiovascular Bioengineering Workshop and Symposium.
Circulation research May, 2017 | Pubmed ID: 28546353
Overcoming the Roadblocks to Cardiac Cell Therapy Using Tissue Engineering.
Journal of the American College of Cardiology Aug, 2017 | Pubmed ID: 28774384
CCND2 Overexpression Enhances the Regenerative Potency of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Remuscularization of Injured Ventricle.
Circulation research Jan, 2018 | Pubmed ID: 29018036
Pathologic Stimulus Determines Lineage Commitment of Cardiac C-kit Cells.
Circulation Dec, 2017 | Pubmed ID: 29021323
VEGF nanoparticles repair the heart after myocardial infarction.
American journal of physiology. Heart and circulatory physiology 02, 2018 | Pubmed ID: 29101176
Large Cardiac Muscle Patches Engineered From Human Induced-Pluripotent Stem Cell-Derived Cardiac Cells Improve Recovery From Myocardial Infarction in Swine.
Circulation Apr, 2018 | Pubmed ID: 29233823
Spheroids of cardiomyocytes derived from human-induced pluripotent stem cells improve recovery from myocardial injury in mice.
American journal of physiology. Heart and circulatory physiology Aug, 2018 | Pubmed ID: 29631371
Can We Engineer a Human Cardiac Patch for Therapy?
Circulation research Jul, 2018 | Pubmed ID: 29976691
Regenerative Potential of Neonatal Porcine Hearts.
Circulation Dec, 2018 | Pubmed ID: 30030418
Y-27632 preconditioning enhances transplantation of human-induced pluripotent stem cell-derived cardiomyocytes in myocardial infarction mice.
Cardiovascular research Feb, 2019 | Pubmed ID: 30107391
Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure.
Circulation research Jan, 2019 | Pubmed ID: 30605412
Enhancing the Engraftment of Human Induced Pluripotent Stem Cell-derived Cardiomyocytes via a Transient Inhibition of Rho Kinase Activity
Meng Zhao1,
Yawen Tang1,
Patrick J. Ernst1,2,
Asher Kahn-Krell1,
Chengming Fan1,3,
Danielle Pretorius1,
Hanxi Zhu1,
Xi Lou1,
Lufang Zhou2,
Jianyi Zhang1,
Wuqiang Zhu1
1Department of Biomedical Engineering, School of Medicine, School of Engineering, University of Alabama at Birmingham,
2Division of Cardiovascular Diseases, School of Medicine, School of Engineering, University of Alabama at Birmingham,
3Department of Cardiac Surgery, The Second Xiangya Hospital of Central South University
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