Gino Villetti

Corporate Preclinical R&D, Chiesi Farmaceutici S.p.A.

Affiliated withChiesi Farmaceutici S.p.A.

Research Area

Immunology and Infection

Biography

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JoVE Journal Publications

Article Total : 2	Year
Publication title	2017
Publication title	2018

Other Publications

Article	Year
Neuroprotective activity of CHF3381, a putative N-methyl-D-aspartate receptor antagonist. Neuroreport\| PubMed ID: 12438928	2002
The protective effect of ganstigmine against amyloid beta 25-35 neurotoxicity on chicken cortical neurons is independent from the cholinesterase inhibition. Neuroscience letters\| PubMed ID: 12697278	2003
Antinociceptive activity of the N-methyl-D-aspartate receptor antagonist N-(2-Indanyl)-glycinamide hydrochloride (CHF3381) in experimental models of inflammatory and neuropathic pain. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 12750440	2003
Mechanisms of action of CHF3381 in the forebrain. British journal of pharmacology\| PubMed ID: 12890713	2003
Ganstigmine and donepezil improve neurodegeneration in AD11 antinerve growth factor transgenic mice. American journal of Alzheimer's disease and other dementias\| PubMed ID: 15214201	2004
High throughput screening of beta-amyloid secretion inhibitors using homogenous time-resolved fluorescence. Combinatorial chemistry & high throughput screening\| PubMed ID: 15578936	2004
CHF3381, a novel antinociceptive agent, attenuates capsaicin-induced pain in rats. European journal of pharmacology\| PubMed ID: 16125167	2005
Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. Journal of medicinal chemistry\| PubMed ID: 16134939	2005
Synthesis and anticonvulsant activity of a class of 2-amino 3-hydroxypropanamide and 2-aminoacetamide derivatives. Bioorganic & medicinal chemistry\| PubMed ID: 16460950	2006
Pharmacological assessment of the duration of action of glycopyrrolate vs tiotropium and ipratropium in guinea-pig and human airways. British journal of pharmacology\| PubMed ID: 16565730	2006
Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819). Journal of medicinal chemistry\| PubMed ID: 16913695	2006
Conformation-sensitive antibodies against alzheimer amyloid-beta by immunization with a thioredoxin-constrained B-cell epitope peptide. The Journal of biological chemistry\| PubMed ID: 17267402	2007
In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents. Pharmacological research\| PubMed ID: 17292621	2007
Formoterol and beclomethasone dipropionate interact positively in antagonising bronchoconstriction and inflammation in the lung. Pharmacological research\| PubMed ID: 17336541	2007
Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 1). Journal of medicinal chemistry\| PubMed ID: 17352462	2007
Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 2). Journal of medicinal chemistry\| PubMed ID: 17352463	2007
1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of ... The Journal of pharmacology and experimental therapeutics\| PubMed ID: 17895400	2007
CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD\| PubMed ID: 20164581	2010
Evaluation of lung inflammation induced by intratracheal administration of LPS in mice: comparison between MRI and histology. Magma (New York, N.Y.)\| PubMed ID: 20386954	2010
Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissu... FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 20720158	2010
The γ-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice. Journal of Alzheimer's disease : JAD\| PubMed ID: 21321397	2011
Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer. Thorax\| PubMed ID: 21460372	2011
Therapeutic effect of CHF5074, a new γ-secretase modulator, in a mouse model of scrapie. Prion\| PubMed ID: 22453180	2012
In vivo imaging of transiently transgenized mice with a bovine interleukin 8 (CXCL8) promoter/luciferase reporter construct. PloS one\| PubMed ID: 22761878	2012
Receptor for advanced glycation end products contributes to postnatal pulmonary development and adult lung maintenance program in mice. American journal of respiratory cell and molecular biology\| PubMed ID: 23144333	2013
Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice. BMC neuroscience\| PubMed ID: 23560952	2013
Novel class of benzoic acid ester derivatives as potent PDE4 inhibitors for inhaled administration in the treatment of respiratory diseases. Journal of medicinal chemistry\| PubMed ID: 24400806	2014
Enlightened Mannhemia haemolytica lung inflammation in bovinized mice. Veterinary research\| PubMed ID: 24460618	2014
Azithromycin inhibits nuclear factor-κB activation during lung inflammation: an in vivo imaging study. Pharmacology research & perspectives\| PubMed ID: 25505605	2014
CHF6001 II: a novel phosphodiesterase 4 inhibitor, suitable for topical pulmonary administration--in vivo preclinical pharmacology profile defines a potent anti-inflammatory compound with a ... The Journal of pharmacology and experimental therapeutics\| PubMed ID: 25576073	2015
CHF6001 I: a novel highly potent and selective phosphodiesterase 4 inhibitor with robust anti-inflammatory activity and suitable for topical pulmonary administration. The Journal of pharmacology and experimental therapeutics\| PubMed ID: 25576075	2015
In vivo imaging of the lung inflammatory response to Pseudomonas aeruginosa and its modulation by azithromycin. Journal of translational medicine\| PubMed ID: 26239109	2015
Monitoring inflammation and airway remodeling by fluorescence molecular tomography in a chronic asthma model. Journal of translational medicine\| PubMed ID: 26496719	2015
Assessment of asthmatic inflammation using hybrid fluorescence molecular tomography-x-ray computed tomography. Journal of biomedical optics\| PubMed ID: 26803669	2016
Anti-inflammatory effects of the novel inhaled phosphodiesterase type 4 inhibitor CHF6001 on virus-inducible cytokines. Pharmacology research & perspectives\| PubMed ID: 26977295	2016
In vivo monitoring of lung inflammation in CFTR-deficient mice. Journal of translational medicine\| PubMed ID: 27468800	2016
Physiological, Biochemical, and Biophysical Characterization of the Lung-Lavaged Spontaneously-Breathing Rabbit as a Model for Respiratory Distress Syndrome. PloS one\| PubMed ID: 28060859	2017
Heterologous Matrix Metalloproteinase Gene Promoter Activity Allows In Vivo Real-time Imaging of Bleomycin-Induced Lung Fibrosis in Transiently Transgenized Mice. Frontiers in immunology\| PubMed ID: 28298912	2017
Longitudinal assessment of bleomycin-induced lung fibrosis by Micro-CT correlates with histological evaluation in mice. Multidisciplinary respiratory medicine\| PubMed ID: 28400960	2017
The PDE4 inhibitor CHF-6001 and LAMAs inhibit bronchoconstriction-induced remodelling in lung slices. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 28596292	2017
Discovery and Optimization of Thiazolidinyl and Pyrrolidinyl Derivatives as Inhaled PDE4 Inhibitors for Respiratory Diseases. Journal of medicinal chemistry\| PubMed ID: 29200281	2017