Thomas Fleming

Department of Medicine I and Clinical Chemistry, University Hospital of Heidelberg

Affiliated withUniversity Hospital of Heidelberg German Center for Diabetes Research (DZD)Heidelberg University

Research Area

NeuroscienceBiochemistry

Biography

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JoVE Journal Publications

Article Total : 2	Year
Publication title	2017
Publication title	2018

Other Publications

Article	Year
Reactive metabolites as a cause of late diabetic complications. Biochemical Society transactions\| PubMed ID: 24646257	2014
High tissue glucose alters intersomitic blood vessels in zebrafish via methylglyoxal targeting the VEGF receptor signaling cascade. Diabetes\| PubMed ID: 25092676	2015
Methylglyoxal as a new biomarker in patients with septic shock: an observational clinical study. Critical care (London, England)\| PubMed ID: 25498125	2014
Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous ce... Molecular cancer\| PubMed ID: 26634247	2015
Role of the RAGE Axis during the Immune Response after Severe Trauma: A Prospective Pilot Study. Mediators of inflammation\| PubMed ID: 26880860	2015
Receptor for advanced glycation end products (RAGE) knockout reduces fetal dysmorphogenesis in murine diabetic pregnancy. Reproductive toxicology (Elmsford, N.Y.)\| PubMed ID: 27109771	2016
RAGE-mediated inflammation in patients with septic shock. The Journal of surgical research\| PubMed ID: 27229106	2016
Impaired glyoxalase activity is associated with reduced expression of neurotrophic factors and pro-inflammatory processes in diabetic skin cells. Experimental dermatology\| PubMed ID: 27306297	2017
Soluble TREM-1 as a diagnostic and prognostic biomarker in patients with septic shock: an observational clinical study. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals\| PubMed ID: 27319606	2017
Characterization of aggregate load and pattern in living yeast cells by flow cytometry. BioTechniques\| PubMed ID: 27625208	2016
Reduction in ins-7 gene expression in non-neuronal cells of high glucose exposed Caenorhabditis elegans protects from reactive metabolites, preserves neuronal structure and head motility, an... Journal of diabetes and its complications\| PubMed ID: 27776915	2017
Control of diabetic hyperglycaemia and insulin resistance through TSC22D4. Nature communications\| PubMed ID: 27827363	2016
Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal Detoxification. The Journal of biological chemistry\| PubMed ID: 27903648	2017
The Glyoxalase System and Methylglyoxal-Derived Carbonyl Stress in Sepsis: Glycotoxic Aspects of Sepsis Pathophysiology. International journal of molecular sciences\| PubMed ID: 28304355	2017
STZ causes depletion of immune cells in sciatic nerve and dorsal root ganglion in experimental diabetes. Journal of neuroimmunology\| PubMed ID: 28385191	2017
Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention. International journal of molecular sciences\| PubMed ID: 28475116	2017
Electrical Muscle Stimulation Induces an Increase of VEGFR2 on Circulating Hematopoietic Stem Cells in Patients With Diabetes. Clinical therapeutics\| PubMed ID: 28554530	2017
Dietary sugars, not lipids, drive hypothalamic inflammation. Molecular metabolism\| PubMed ID: 28752053	2017
Reply to Richarme: Evidence against a role of DJ-1 in methylglyoxal detoxification. The Journal of biological chemistry\| PubMed ID: 28778882	2017
A Hepatic GAbp-AMPK Axis Links Inflammatory Signaling to Systemic Vascular Damage. Cell reports\| PubMed ID: 28793265	2017
Hormesis enables cells to handle accumulating toxic metabolites during increased energy flux. Redox biology\| PubMed ID: 28826004	2017
Homeostatic nuclear RAGE-ATM interaction is essential for efficient DNA repair. Nucleic acids research\| PubMed ID: 28977635	2017
The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice. Redox biology\| PubMed ID: 29195137	2018
Modulation of glutathione peroxidase activity by age-dependent carbonylation in glomeruli of diabetic mice. Journal of diabetes and its complications\| PubMed ID: 29223856	2017
TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation. Molecular metabolism\| PubMed ID: 29373286	2018
High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in . The Journal of biological chemistry\| PubMed ID: 29414769	2018
Effects of the Reactive Metabolite Methylglyoxal on Cellular Signalling, Insulin Action and Metabolism - What We Know in Mammals and What We Can Learn From Yeast. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association\| PubMed ID: 29421830	2018
Risk Factors for Incident Diabetic Polyneuropathy in a Cohort With Screen-Detected Type 2 Diabetes Followed for 13 Years: ADDITION-Denmark. Diabetes care\| PubMed ID: 29487078	2018
Impact of carbonylation on glutathione peroxidase-1 activity in human hyperglycemic endothelial cells. Redox biology\| PubMed ID: 29499564	2018
Cell cycle arrest and cell death correlate with the extent of ischaemia and reperfusion injury in patients following kidney transplantation - results of an observational pilot study. Transplant international : official journal of the European Society for Organ Transplantation\| PubMed ID: 29505681	2018
Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes. Cell metabolism\| PubMed ID: 29551588	2018
Carnosine Catalyzes the Formation of the Oligo/Polymeric Products of Methylglyoxal. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology\| PubMed ID: 29621776	2018
Impairment of the Akt pathway in transplanted Type 1 diabetic hearts is associated with post-transplant graft injury. Interactive cardiovascular and thoracic surgery\| PubMed ID: 29912386	2018
Dietary stearic acid regulates mitochondria in vivo in humans. Nature communications\| PubMed ID: 30087348	2018