Thomas Fleming

Reactive metabolites as a cause of late diabetic complications.

High tissue glucose alters intersomitic blood vessels in zebrafish via methylglyoxal targeting the VEGF receptor signaling cascade.

Methylglyoxal as a new biomarker in patients with septic shock: an observational clinical study.

Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma.

Role of the RAGE Axis during the Immune Response after Severe Trauma: A Prospective Pilot Study.

Receptor for advanced glycation end products (RAGE) knockout reduces fetal dysmorphogenesis in murine diabetic pregnancy.

RAGE-mediated inflammation in patients with septic shock.

Impaired glyoxalase activity is associated with reduced expression of neurotrophic factors and pro-inflammatory processes in diabetic skin cells.

Soluble TREM-1 as a diagnostic and prognostic biomarker in patients with septic shock: an observational clinical study.

Characterization of aggregate load and pattern in living yeast cells by flow cytometry.

Reduction in ins-7 gene expression in non-neuronal cells of high glucose exposed Caenorhabditis elegans protects from reactive metabolites, preserves neuronal structure and head motility, and prolongs lifespan.

Control of diabetic hyperglycaemia and insulin resistance through TSC22D4.

Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal Detoxification.

The Glyoxalase System and Methylglyoxal-Derived Carbonyl Stress in Sepsis: Glycotoxic Aspects of Sepsis Pathophysiology.

STZ causes depletion of immune cells in sciatic nerve and dorsal root ganglion in experimental diabetes.

Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention.

Electrical Muscle Stimulation Induces an Increase of VEGFR2 on Circulating Hematopoietic Stem Cells in Patients With Diabetes.

Dietary sugars, not lipids, drive hypothalamic inflammation.

Reply to Richarme: Evidence against a role of DJ-1 in methylglyoxal detoxification.

A Hepatic GAbp-AMPK Axis Links Inflammatory Signaling to Systemic Vascular Damage.

Hormesis enables cells to handle accumulating toxic metabolites during increased energy flux.

Homeostatic nuclear RAGE-ATM interaction is essential for efficient DNA repair.

The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice.

Modulation of glutathione peroxidase activity by age-dependent carbonylation in glomeruli of diabetic mice.

TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation.

High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in .

Effects of the Reactive Metabolite Methylglyoxal on Cellular Signalling, Insulin Action and Metabolism - What We Know in Mammals and What We Can Learn From Yeast.

Risk Factors for Incident Diabetic Polyneuropathy in a Cohort With Screen-Detected Type 2 Diabetes Followed for 13 Years: ADDITION-Denmark.

Impact of carbonylation on glutathione peroxidase-1 activity in human hyperglycemic endothelial cells.

Cell cycle arrest and cell death correlate with the extent of ischaemia and reperfusion injury in patients following kidney transplantation - results of an observational pilot study.

Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes.

Carnosine Catalyzes the Formation of the Oligo/Polymeric Products of Methylglyoxal.

Impairment of the Akt pathway in transplanted Type 1 diabetic hearts is associated with post-transplant graft injury.

Dietary stearic acid regulates mitochondria in vivo in humans.