Christian Betzel

Institute for Biochemistry and Molecular Biology, University of Hamburg

Affiliated withUniversity of Hamburg Integrated Biology Infrastructure Life-Science Facility at the European XFEL (XBI)

Research Area

BiochemistryChemistry

Biography

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JoVE Journal Publications

ArticleTotal : 2	Year
Publication title	2018
$Microfluidic Chips for <em>In Situ</em> Crystal X-ray Diffraction and <em>In Situ</em> Dynamic Light Scattering for Serial Crystallography$ Publication title	2018

Other Publications

Article	Year
Native and inhibited structure of a Mu class-related glutathione S-transferase from Plasmodium falciparum. The Journal of biological chemistry\| PubMed ID: 12972411	2004
Structure of the major cytosolic glutathione S-transferase from the parasitic nematode Onchocerca volvulus. The Journal of biological chemistry\| PubMed ID: 15640152	2005
Mistletoe lectin I in complex with galactose and lactose reveals distinct sugar-binding properties. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 16508080	2005
Interactions of recombinant prions with compounds of therapeutical significance. Biochemical and biophysical research communications\| PubMed ID: 16630566	2006
Crystallization and preliminary X-ray diffraction analysis of a tRNASer acceptor-stem microhelix. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 16754981	2006
Comparative crystallization and preliminary X-ray diffraction studies of locked nucleic acid and RNA stems of a tenascin C-binding aptamer. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 16820689	2006
Catalytic efficiencies of alkaline proteinases from microorganisms. Zeitschrift fur Naturforschung. C, Journal of biosciences\| PubMed ID: 16869506	2006
Purification, crystallization and preliminary X-ray study of the fungal laccase from Cerrena maxima. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 17012782	2006
Crystallization and preliminary X-ray diffraction analysis of an Escherichia coli tRNA(Gly) acceptor-stem microhelix. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 17183173	2007
Crystallization and preliminary X-ray diffraction studies of trypsin-like proteases from the gastric fluid of the marine crab Cancer pagurus. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 17329824	2007
First experimental evidence for the preferential stabilization of the natural D- over the nonnatural L-configuration in nucleic acids. RNA (New York, N.Y.)\| PubMed ID: 17804644	2007
Cocrystallizing natural RNA with its unnatural mirror image: biochemical and preliminary X-ray diffraction analysis of a 5S rRNA A-helix racemate. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 17909284	2007
Isolation, crystallization and preliminary crystallographic analysis of Salmonella typhimurium uridine phosphorylase crystallized with 2,2'-anhydrouridine. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 17909287	2007
Human tRNA(Gly) acceptor-stem microhelix: crystallization and preliminary X-ray diffraction analysis at 1.2 A resolution. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 17909289	2007
Comparative analysis of the venom proteomes of Vipera ammodytes ammodytes and Vipera ammodytes meridionalis. Journal of proteome research\| PubMed ID: 18257516	2008
Autoproteolytic stability of a trypsin from the marine crab Cancer pagurus. Biochemical and biophysical research communications\| PubMed ID: 18395521	2008
Structure of mistletoe lectin I from Viscum album in complex with the phytohormone zeatin. Biochimica et biophysica acta\| PubMed ID: 18718563	2008
Isolation, crystallization and preliminary X-ray diffraction analysis of L-amino-acid oxidase from Vipera ammodytes ammodytes venom. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 18931435	2008
Proteome analysis of snake venom toxins: pharmacological insights. Expert review of proteomics\| PubMed ID: 19086859	2008
X-ray diffraction analysis of a human tRNA(Gly) acceptor-stem microhelix isoacceptor at 1.18 A resolution. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 19153458	2009
Escherichia coli tRNA(Arg) acceptor-stem isoacceptors: comparative crystallization and preliminary X-ray diffraction analysis. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 19193994	2009
UV-light-induced conversion and aggregation of prion proteins. Free radical biology & medicine\| PubMed ID: 19249347	2009
Peptide NMHRYPNQ of the cellular prion protein (PrP(C)) inhibits aggregation and is a potential key for understanding prion-prion interactions. Journal of molecular biology\| PubMed ID: 19607841	2009
Crystallization and X-ray diffraction analysis of an 'all-locked' nucleic acid duplex derived from a tRNA(Ser) microhelix. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 19652346	2009
Crystallization and preliminary X-ray diffraction data of an LNA 7-mer duplex derived from a ricin aptamer. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 19724123	2009
Snake venomic of Crotalus durissus terrificus--correlation with pharmacological activities. Journal of proteome research\| PubMed ID: 20205475	2010
Efficient UV detection of protein crystals enabled by fluorescence excitation at wavelengths longer than 300 nm. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 20383027	2010
Three-dimensional model of the honeybee venom allergen Api m 7: structural and functional insights. Molecular bioSystems\| PubMed ID: 20485747	2010
The crystal structure of an 'All Locked' nucleic acid duplex. Nucleic acids research\| PubMed ID: 20530536	2010
CHL1 is a selective organizer of the presynaptic machinery chaperoning the SNARE complex. PloS one\| PubMed ID: 20711454	2010
The structure of a native l-amino acid oxidase, the major component of the Vipera ammodytes ammodytes venomic, reveals dynamic active site and quaternary structure stabilization by divalent ... Molecular bioSystems\| PubMed ID: 20938508	2011
Purification, crystallization and preliminary X-ray diffraction analysis of the thiaminase type II from Staphylococcus aureus. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 21206023	2011
Isolation, purification, crystallization and preliminary crystallographic studies of a chitinase from Crocus vernus. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 21393839	2011
Pseudechis australis venomics: adaptation for a defense against microbial pathogens and recruitment of body transferrin. Journal of proteome research\| PubMed ID: 21417486	2011
Purification, crystallization and preliminary X-ray diffraction analysis of ThiM from Staphylococcus aureus. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 21505246	2011
Three-dimensional modelling of honeybee venom allergenic proteases: relation to allergenicity. Zeitschrift fur Naturforschung. C, Journal of biosciences\| PubMed ID: 21812349	2011
Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy. The Journal of biological chemistry\| PubMed ID: 21917929	2011
Venom peptide analysis of Vipera ammodytes meridionalis (Viperinae) and Bothrops jararacussu (Crotalinae) demonstrates subfamily-specificity of the peptidome in the family Viperidae. Molecular bioSystems\| PubMed ID: 21959992	2011
In vivo protein crystallization opens new routes in structural biology. Nature methods\| PubMed ID: 22286384	2012
Crystallization and preliminary X-ray diffraction analysis of an L-amino-acid oxidase from Bothrops jararacussu venom. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 22298002	2012
Heating Affects Structure, Enterocyte Adsorption and Signalling, As Well as Immunogenicity of the Peanut Allergen Ara h 2. The open allergy journal\| PubMed ID: 22318448	2011
Crystal structure of a dimeric Ser49- PLA₂-like myotoxic component of the Vipera ammodytes meridionalis venomics reveals determinants of myotoxicity and membrane damaging activity. Molecular bioSystems\| PubMed ID: 22362132	2012
Features of "All LNA" Duplexes Showing a New Type of Nucleic Acid Geometry. Journal of nucleic acids\| PubMed ID: 22666550	2012
Monitoring and scoring counter-diffusion protein crystallization experiments in capillaries by in situ dynamic light scattering. PloS one\| PubMed ID: 22675464	2012
Single-drop optimization of protein crystallization. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 22869140	2012
Purification, crystallization and preliminary X-ray diffraction analysis of crotamine, a myotoxic polypeptide from the Brazilian snake Crotalus durissus terrificus. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 22949192	2012
Structure of the recombinant BPTI/Kunitz-type inhibitor rShPI-1A from the marine invertebrate Stichodactyla helianthus. Acta crystallographica. Section F, Structural biology and crystallization communications\| PubMed ID: 23143234	2012
Natively inhibited Trypanosoma brucei cathepsin B structure determined by using an X-ray laser. Science (New York, N.Y.)\| PubMed ID: 23196907	2013
Production, purification and characterization of recombinant, full-length human claudin-1. PloS one\| PubMed ID: 23704991	2013
Staphylococcus aureus thiaminase II: oligomerization warrants proteolytic protection against serine proteases. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 24311574	2013
Crystallization and preliminary X-ray study of Vibrio cholerae uridine phosphorylase in complex with 6-methyluracil. Acta crystallographica. Section F, Structural biology communications\| PubMed ID: 24419619	2014
Elapid snake venom analyses show the specificity of the peptide composition at the level of genera Naja and Notechis. Toxins\| PubMed ID: 24590383	2014
Preliminary crystallographic analysis of a cruciferin protein from seeds of Moringa oleifera. The protein journal\| PubMed ID: 24705831	2014
Serial crystallography on in vivo grown microcrystals using synchrotron radiation. IUCrJ\| PubMed ID: 25075324	2014
Room-temperature macromolecular serial crystallography using synchrotron radiation. IUCrJ\| PubMed ID: 25075341	2014
Structure-based identification of inositol polyphosphate 1-phosphatase from Entamoeba histolytica. Acta crystallographica. Section D, Biological crystallography\| PubMed ID: 25372691	2014
Utilisation of adsorption and desorption for simultaneously improving protein crystallisation success rate and crystal quality. Scientific reports\| PubMed ID: 25471817	2014
Isolation, identification and functional profile of excretory-secretory peptides from Onchocerca ochengi. Acta tropica\| PubMed ID: 25479441	2015
Systematic analysis of protein-detergent complexes applying dynamic light scattering to optimize solutions for crystallization trials. Acta crystallographica. Section F, Structural biology communications\| PubMed ID: 25615974	2015
Latest methods of fluorescence-based protein crystal identification. Acta crystallographica. Section F, Structural biology communications\| PubMed ID: 25664782	2015
Three-dimensional Structure of a Kunitz-type Inhibitor in Complex with an Elastase-like Enzyme. The Journal of biological chemistry\| PubMed ID: 25878249	2015
Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2. Nature communications\| PubMed ID: 25901662	2015
High resolution structures of Plasmodium falciparum GST complexes provide novel insights into the dimer-tetramer transition and a novel ligand-binding site. Journal of structural biology\| PubMed ID: 26072058	2015
Introduction to selected articles from the 15th ICCBM. Acta crystallographica. Section F, Structural biology communications\| PubMed ID: 26144223	2015
In vivo protein crystallization in combination with highly brilliant radiation sources offers novel opportunities for the structural analysis of post-translationally modified eukaryotic prot... Acta crystallographica. Section F, Structural biology communications\| PubMed ID: 26249677	2015
Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta-mediated neurotoxicity. Journal of neurochemistry\| PubMed ID: 26710111	2016
Isolation and characterization of Bradykinin potentiating peptides from Agkistrodon bilineatus venom. Proteome science\| PubMed ID: 26770072	2016
Structural investigation of the thymidine phosphorylase from Salmonella typhimurium in the unliganded state and its complexes with thymidine and uridine. Acta crystallographica. Section F, Structural biology communications\| PubMed ID: 26919527	2016
Two variants of the major serine protease inhibitor from the sea anemone Stichodactyla helianthus, expressed in Pichia pastoris. Protein expression and purification\| PubMed ID: 26993255	2016
Analysis of self-assembly of S-layer protein slp-B53 from Lysinibacillus sphaericus. European biophysics journal : EBJ\| PubMed ID: 27270294	2017
Atomic Structure and Biochemical Characterization of an RNA Endonuclease in the N Terminus of Andes Virus L Protein. PLoS pathogens\| PubMed ID: 27300328	2016
Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells. PLoS pathogens\| PubMed ID: 27300509	2016
A multicrystal diffraction data-collection approach for studying structural dynamics with millisecond temporal resolution. IUCrJ\| PubMed ID: 27840678	2016
Protein Profile Analysis of Two Australian Snake Venoms by One- Dimensional Gel Electrophoresis and MS/MS Experiments. Current medicinal chemistry\| PubMed ID: 28571558	2017
Spider's venom phospholipases D: A structural review. International journal of biological macromolecules\| PubMed ID: 28951301	2018
Highly affine and selective aptamers against cholera toxin as capture elements in magnetic bead-based sandwich ELAA. Journal of biotechnology\| PubMed ID: 29408200	2018
Thrombin-like enzymes from snake venom: Structural characterization and mechanism of action. International journal of biological macromolecules\| PubMed ID: 29604354	2018
Crystal Structure of Mistletoe Lectin I (ML-I) from Viscum album in Complex with 4-N-Furfurylcytosine at 2.85 Å Resolution. Medicinal chemistry (Shariqah (United Arab Emirates))\| PubMed ID: 29792147	2018