Department of Perioperative Medicine
Matthieu Jabaudon, MD PhD
Associate Professor of Medicine
Department of Perioperative Medicine, CHU Clermont-Ferrand
Team « Translational Approach to epithelial injury and repair”, GReD, Universite Clermont Auvergne, CNRS, INSERM
58 rue Montalembert, 63000Clermont-Ferrand, France
Email: mjabaudon@chu.clermontferrand.fr
Education
MD in Anesthesiology, Critical Care and Perioperative Medicine - Université Clermont Auvergne
PhD in Biological Sciences - Université Clermont Auvergne, GReD, CNRS, INSERM
Postgraduate Training
Visiting Associate Professor of Medicine, Vanderbilt University Medical Center (2019-2020)
Clinical Interest
Dr. Jabaudon cares for critically ill patients in the CHU Clermont-Ferrand Unit where he is passionate about providing outstanding patient care and training the next generation of anesthesiology and critical care physicians. He has a particular interest in acute respiratory distress syndrome and mechanical ventilation.
Research Keywords
Translational research in acute lung injury and repair.
Research Description
Our Hospital research team and University lab do basic, translational and clinical research on the role of the alveolar epithelium in the pathogenesis and resolution of acute lung injury and the acute respiratory distress syndrome (ARDS). Current projects include studies of the effects of inhaled anesthetics (sevoflurane, isoflurane) in acute lung injury and repair, investigation of the role of the receptor for advanced glycation end-products (RAGE) pathway and of the alveolar epithelium in the pathogenesis and resolution of acute lung injury, and translational studies of biomarkers for diagnosis and prognosis in acute lung injury
Publications
https://pubmed.ncbi.nlm.nih.gov/?term=jabaudon+m&sort=date
Soluble form of the receptor for advanced glycation end products is a marker of acute lung injury but not of severe sepsis in critically ill patients.
Critical care medicine Mar, 2011 | Pubmed ID: 21220996
Plasma levels of sRAGE, loss of aeration and weaning failure in ICU patients: a prospective observational multicenter study.
PloS one , 2013 | Pubmed ID: 23724022
Low Molecular Weight Heparin Induced Skin Necrosis without Platelet Fall Revealing Immunoallergic Heparin Induced Thrombocytopenia.
Case reports in hematology , 2013 | Pubmed ID: 24307958
Effects of a recruitment maneuver on plasma levels of soluble RAGE in patients with diffuse acute respiratory distress syndrome: a prospective randomized crossover study.
Intensive care medicine May, 2015 | Pubmed ID: 25792206
Soluble Receptor for Advanced Glycation End-Products Predicts Impaired Alveolar Fluid Clearance in Acute Respiratory Distress Syndrome.
American journal of respiratory and critical care medicine Jul, 2015 | Pubmed ID: 25932660
Novel CO2 removal device driven by a renal-replacement system without hemofilter. A first step experimental validation.
Anaesthesia, critical care & pain medicine Jun, 2015 | Pubmed ID: 26004872
Epidural analgesia in the intensive care unit: An observational series of 121 patients.
Anaesthesia, critical care & pain medicine Aug, 2015 | Pubmed ID: 26004880
Soluble Forms and Ligands of the Receptor for Advanced Glycation End-Products in Patients with Acute Respiratory Distress Syndrome: An Observational Prospective Study.
PloS one , 2015 | Pubmed ID: 26274928
Net alveolar fluid clearance is associated with lung morphology phenotypes in acute respiratory distress syndrome.
Anaesthesia, critical care & pain medicine Apr, 2016 | Pubmed ID: 26926951
A Pathophysiologic Approach to Biomarkers in Acute Respiratory Distress Syndrome.
Disease markers , 2016 | Pubmed ID: 26980924
Sevoflurane for Sedation in Acute Respiratory Distress Syndrome. A Randomized Controlled Pilot Study.
American journal of respiratory and critical care medicine 03, 2017 | Pubmed ID: 27611637
Epidural analgesia in critically ill patients with acute pancreatitis: the multicentre randomised controlled EPIPAN study protocol.
BMJ open 05, 2017 | Pubmed ID: 28554928
RAGE inhibition reduces acute lung injury in mice.
Scientific reports Aug, 2017 | Pubmed ID: 28775380
Recruitment maneuvers in acute respiratory distress syndrome.
Annals of translational medicine Jul, 2017 | Pubmed ID: 28828365
Recent directions in personalised acute respiratory distress syndrome medicine.
Anaesthesia, critical care & pain medicine Jun, 2018 | Pubmed ID: 28935455
Thoracic Epidural Analgesia and Mortality in Acute Pancreatitis: A Multicenter Propensity Analysis.
Critical care medicine Mar, 2018 | Pubmed ID: 29194144
High frequency percussive ventilation increases alveolar recruitment in early acute respiratory distress syndrome: an experimental, physiological and CT scan study.
Critical care (London, England) Jan, 2018 | Pubmed ID: 29325586
Receptor for advanced glycation end-products and ARDS prediction: a multicentre observational study.
Scientific reports Feb, 2018 | Pubmed ID: 29422518
Distinct Biological Effects of Time-Controlled Adaptive Ventilation in Pulmonary and Extrapulmonary Acute Respiratory Distress Syndrome: "One Small Step for Rats, One Giant Leap for Humans?"
Critical care medicine Jun, 2018 | Pubmed ID: 29762415
Clinical and Biological Predictors of Plasma Levels of Soluble RAGE in Critically Ill Patients: Secondary Analysis of a Prospective Multicenter Observational Study.
Disease markers , 2018 | Pubmed ID: 29861796
The authors reply.
Critical care medicine Jul, 2018 | Pubmed ID: 29912120
Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data.
Intensive care medicine Sep, 2018 | Pubmed ID: 30051136
Serum soluble receptor for advanced glycation end-products during acute bronchiolitis in infant: Prospective study in 93 cases.
Pediatric pulmonology Oct, 2018 | Pubmed ID: 30113140
Driving pressure and acute respiratory distress syndrome in critically ill patients.
Respirology (Carlton, Vic.) Sep, 2018 | Pubmed ID: 30183115
Pathological Implications of Receptor for Advanced Glycation End-Product () Gene Polymorphism.
Disease markers , 2019 | Pubmed ID: 30863465
ARDS in patients with chest trauma: Better safe than sorry.
Anaesthesia, critical care & pain medicine 06, 2019 | Pubmed ID: 31076142
Inhibition of the Receptor for Advanced Glycation End-Products in Acute Respiratory Distress Syndrome: A Randomised Laboratory Trial in Piglets.
Scientific reports 06, 2019 | Pubmed ID: 31239497
Encou-RAGE-ing Lung Protection in Patients With Acute Respiratory Distress Syndrome Under Extracorporeal Membrane Oxygenation.
Critical care medicine 11, 2019 | Pubmed ID: 31609260
Epidemiology and prognosis of anti-infective therapy in the ICU setting during acute pancreatitis: a cohort study.
Critical care (London, England) Dec, 2019 | Pubmed ID: 31805988
Eyes wide open on bronchial aeration in acute respiratory distress syndrome.
Anaesthesia, critical care & pain medicine Apr, 2020 | Pubmed ID: 32145431
Advanced Glycation End Products and Receptor (RAGE) Promote Wound Healing of Human Corneal Epithelial Cells.
Investigative ophthalmology & visual science 03, 2020 | Pubmed ID: 32176265
Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis.
Respiratory research Apr, 2020 | Pubmed ID: 32264897
The receptor for advanced glycation end-products enhances lung epithelial wound repair: An in vitro study.
Experimental cell research Jun, 2020 | Pubmed ID: 32330509
Early Changes Over Time in the Radiographic Assessment of Lung Edema Score Are Associated With Survival in ARDS.
Chest Jul, 2020 | Pubmed ID: 32659235
Epidural analgesia in ICU chest trauma patients with fractured ribs: retrospective study of pain control and intubation requirements.
Annals of intensive care Aug, 2020 | Pubmed ID: 32852675
Raïko Blondonnet1,2,
Bertille Paquette1,2,
Damien Richard3,
Rémi Bourg2,4,
Géraldine Laplace2,4,
Romain Segurel2,4,
Henria Pouvelle2,4,
Corinne Belville2,
Loic Blanchon2,
Thomas Godet1,2,
Jean-Michel Constantin1,2,
Jean-Etienne Bazin1,2,
Vincent Sapin2,
Matthieu Jabaudon1,2
1Department of Perioperative Medicine, CHU Clermont-Ferrand,
2Centre National de la Recherche Scientifique Unité Mixte de Recherche (CNRS UMR) 6293, Institut National de la Santé et de la Recherche Médicale (INSERM) U1103, Laboratoire de Génétique, Reproduction et Développement (GReD), Université Clermont Auvergne,
3Department of Pharmacology, CHU Clermont-Ferrand,
4Nurse Anesthetist School, CHU Clermont-Ferrand
Raiko Blondonnet1,2,
Bertille Paquette1,2,
Jules Audard1,2,
Ridvan Guler1,2,
François-Xavier Roman1,2,
Ruoyang Zhai2,
Corinne Belville2,
Loïc Blanchon2,
Thomas Godet1,
Emmanuel Futier1,2,
Jean-Etienne Bazin1,
Jean-Michel Constantin3,
Vincent Sapin2,4,
Matthieu Jabaudon1,2,5
1Department of Perioperative Medicine, CHU Clermont-Ferrand,
2GReD, CNRS, INSERM, Université Clermont Auvergne,
3GRC 29, AP-HP, DMU DREAM, Department of Anesthesiology and Critical Care, Pitié-Salpêtrière Hospital, Sorbonne University,
4Department of Biochemistry and Molecular Genetics, CHU Clermont-Ferrand,
5Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center
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