Seth Blackshaw

Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine

Affiliated withJohns Hopkins School of Medicine Johns Hopkins University School of Medicine The Johns Hopkins Hospital

Research Area

Neuroscience

Biography

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JoVE Journal Publications

Article Total : 3	Year
Publication title	2011
Publication title	2013
Publication title	2021

Other Publications

Article	Year
Neuronal nitric oxide synthase alternatively spliced forms: prominent functional localizations in the brain. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 9096405	1997
The development of excitatory synapses in cultured spinal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 9295380	1997
Developmental expression pattern of phototransduction components in mammalian pineal implies a light-sensing function. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 9334383	1997
Parapinopsin, a novel catfish opsin localized to the parapineal organ, defines a new gene family. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 9334384	1997
The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1. The Journal of cell biology\| PubMed ID: 9531554	1998
Poly(ADP-ribose) polymerase-deficient mice are protected from streptozotocin-induced diabetes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10077636	1999
A novel neuron-enriched homolog of the erythrocyte membrane cytoskeletal protein 4.1. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 10414974	1999
Poly(ADP-ribosyl)ation basally activated by DNA strand breaks reflects glutamate-nitric oxide neurotransmission. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 10677544	2000
Profile of the genes expressed in the human peripheral retina, macula, and retinal pigment epithelium determined through serial analysis of gene expression (SAGE). Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 11756676	2002
Applying genomics technologies to neural development. Current opinion in neurobiology\| PubMed ID: 11861173	2002
Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa. Human molecular genetics\| PubMed ID: 11875050	2002
The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1. Human molecular genetics\| PubMed ID: 12374762	2002
Stem cells that know their place. Nature neuroscience\| PubMed ID: 12447376	2002
MicroSAGE is highly representative and reproducible but reveals major differences in gene expression among samples obtained from similar tissues. Genome biology\| PubMed ID: 12620102	2003
Genomic analysis of mouse retinal development. PLoS biology\| PubMed ID: 15226823	2004
Clustering analysis of SAGE data using a Poisson approach. Genome biology\| PubMed ID: 15239836	2004
Methionine adenosyltransferase:adrenergic-cAMP mechanism regulates a daily rhythm in pineal expression. The Journal of biological chemistry\| PubMed ID: 15504733	2005
D-aspartate regulates melanocortin formation and function: behavioral alterations in D-aspartate oxidase-deficient mice. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 16525061	2006
Behavioural alterations in male mice lacking the gene for D-aspartate oxidase. Behavioural brain research\| PubMed ID: 16725213	2006
Serial analysis of gene expression (SAGE): experimental method and data analysis. Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.]\| PubMed ID: 18265400	2007
D-Aspartate and D-aspartate oxidase show selective and developmentally dynamic localization in mouse retina. Experimental eye research\| PubMed ID: 18314103	2008
Serial analysis of gene expression (SAGE): experimental method and data analysis. Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.]\| PubMed ID: 18428405	2007
Pias3-dependent SUMOylation directs rod photoreceptor development. Neuron\| PubMed ID: 19186166	2009
New meaning in the message: noncoding RNAs and their role in retinal development. Developmental dynamics : an official publication of the American Association of Anatomists\| PubMed ID: 19191220	2009
Muscleblind-like 2: circadian expression in the mammalian pineal gland is controlled by an adrenergic-cAMP mechanism. Journal of neurochemistry\| PubMed ID: 19457059	2009
Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling. Cell\| PubMed ID: 19879846	2009
hPDI: a database of experimental human protein-DNA interactions. Bioinformatics (Oxford, England)\| PubMed ID: 19900953	2010
A genomic atlas of mouse hypothalamic development. Nature neuroscience\| PubMed ID: 20436479	2010
The long noncoding RNA RNCR2 directs mouse retinal cell specification. BMC developmental biology\| PubMed ID: 20459797	2010
The orphan nuclear hormone receptor ERRbeta controls rod photoreceptor survival. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 20534447	2010
Three-dimensional diffusion tensor microimaging for anatomical characterization of the mouse brain. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine\| PubMed ID: 20577980	2010
Pias3-dependent SUMOylation controls mammalian cone photoreceptor differentiation. Nature neuroscience\| PubMed ID: 20729845	2010
Vertebrate retina and hypothalamus development. Wiley interdisciplinary reviews. Systems biology and medicine\| PubMed ID: 20836003	2009
Functional protein microarray technology. Wiley interdisciplinary reviews. Systems biology and medicine\| PubMed ID: 20872749	2011
Molecular pathways controlling development of thalamus and hypothalamus: from neural specification to circuit formation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 21068293	2010
Dynamic spatiotemporal gene expression in embryonic mouse thalamus. The Journal of comparative neurology\| PubMed ID: 21192082	2011
Region-specific gene expression in early postnatal mouse thalamus. The Journal of comparative neurology\| PubMed ID: 21192083	2011
Systematic characterization of protein-DNA interactions. Cellular and molecular life sciences : CMLS\| PubMed ID: 21207099	2011
Characterization of protein-DNA interactions using protein microarrays. Cold Spring Harbor protocols\| PubMed ID: 21536762	2011
The Spalt family transcription factor Sall3 regulates the development of cone photoreceptors and retinal horizontal interneurons. Development (Cambridge, England)\| PubMed ID: 21558380	2011
We contain multitudes: the protean face of retinoblastoma. Cancer cell\| PubMed ID: 21840479	2011
The long noncoding RNA Six3OS acts in trans to regulate retinal development by modulating Six3 activity. Neural development\| PubMed ID: 21936910	2011
Yeast one-hybrid assays for gene-centered human gene regulatory network mapping. Nature methods\| PubMed ID: 22037702	2011
Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis. Nature chemical biology\| PubMed ID: 22267120	2012
Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. Molecular & cellular proteomics : MCP\| PubMed ID: 22307071	2012
Injury-independent induction of reactive gliosis in retina by loss of function of the LIM homeodomain transcription factor Lhx2. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 22393024	2012
Botch promotes neurogenesis by antagonizing Notch. Developmental cell\| PubMed ID: 22445366	2012
Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche. Nature neuroscience\| PubMed ID: 22446882	2012
Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays. Molecular & cellular proteomics : MCP\| PubMed ID: 22647870	2012
WITHDRAWN: Functional implications of hypothalamic neurogenesis in the adult mammalian brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience\| PubMed ID: 22814121	2012
Functional implications of hypothalamic neurogenesis in the adult mammalian brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience\| PubMed ID: 22867732	2012
High-throughput RNA in situ hybridization in mouse retina. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 23150371	2013
Estrogen-related receptor β deletion modulates whole-body energy balance via estrogen-related receptor γ and attenuates neuropeptide Y gene expression. The European journal of neuroscience\| PubMed ID: 23360481	2013
Construction of human activity-based phosphorylation networks. Molecular systems biology\| PubMed ID: 23549483	2013
Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite. American journal of physiology. Regulatory, integrative and comparative physiology\| PubMed ID: 23576617	2013
LHX2 is necessary for the maintenance of optic identity and for the progression of optic morphogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 23595746	2013
Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. Molecular & cellular proteomics : MCP\| PubMed ID: 23824909	2013
Rax regulates hypothalamic tanycyte differentiation and barrier function in mice. The Journal of comparative neurology\| PubMed ID: 23939786	2013
Estrogen-related receptor beta deficiency alters body composition and response to restraint stress. BMC physiology\| PubMed ID: 24053666	2013
Protein microarray characterization of the S-nitrosoproteome. Molecular & cellular proteomics : MCP\| PubMed ID: 24105792	2013
RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention. Neuron\| PubMed ID: 24139042	2013
Feed your head: neurodevelopmental control of feeding and metabolism. Annual review of physiology\| PubMed ID: 24274739	2014
Stage-specific inhibition of TrkB activity leads to long-lasting and sexually dimorphic effects on body weight and hypothalamic gene expression. PloS one\| PubMed ID: 24312242	2013
Rax-CreERT2 knock-in mice: a tool for selective and conditional gene deletion in progenitor cells and radial glia of the retina and hypothalamus. PloS one\| PubMed ID: 24699247	2014
Lhx1 controls terminal differentiation and circadian function of the suprachiasmatic nucleus. Cell reports\| PubMed ID: 24767996	2014
Long non-coding RNA-dependent transcriptional regulation in neuronal development and disease. Frontiers in genetics\| PubMed ID: 24936207	2014
Dietary and sex-specific factors regulate hypothalamic neurogenesis in young adult mice. Frontiers in neuroscience\| PubMed ID: 24982613	2014
Characterization of the SUMO-binding activity of the myeloproliferative and mental retardation (MYM)-type zinc fingers in ZNF261 and ZNF198. PloS one\| PubMed ID: 25133527	2014
Serine racemase regulated by binding to stargazin and PSD-95: potential N-methyl-D-aspartate-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (NMDA-AMPA) glutamate neurotransmission cros... The Journal of biological chemistry\| PubMed ID: 25164819	2014
Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. PLoS genetics\| PubMed ID: 25356737	2014
The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 25505333	2014
A conserved regulatory logic controls temporal identity in mouse neural progenitors. Neuron\| PubMed ID: 25654255	2015
Patterning, specification, and differentiation in the developing hypothalamus. Wiley interdisciplinary reviews. Developmental biology\| PubMed ID: 25820448	2015
Identification of SUMO E3 ligase-specific substrates using the HuProt human proteome microarray. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 25820740	2015
Constructing the suprachiasmatic nucleus: a watchmaker's perspective on the central clockworks. Frontiers in systems neuroscience\| PubMed ID: 26005407	2015
EphA4 is Involved in Sleep Regulation but Not in the Electrophysiological Response to Sleep Deprivation. Sleep\| PubMed ID: 26612390	2016
Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience\| PubMed ID: 26911688	2016
The nutrient sensor OGT in PVN neurons regulates feeding. Science (New York, N.Y.)\| PubMed ID: 26989246	2016
Penetrance of Congenital Heart Disease in a Mouse Model of Down Syndrome Depends on a Trisomic Potentiator of a Disomic Modifier. Genetics\| PubMed ID: 27029737	2016
Multiple intrinsic factors act in concert with Lhx2 to direct retinal gliogenesis. Scientific reports\| PubMed ID: 27605455	2016
Control of lens development by Lhx2-regulated neuroretinal FGFs. Development (Cambridge, England)\| PubMed ID: 27633990	2016
The NIH Protein Capture Reagents Program (PCRP): a standardized protein affinity reagent toolbox. Nature methods\| PubMed ID: 27684578	2016
The stage-dependent roles of Ldb1 and functional redundancy with Ldb2 in mammalian retinogenesis. Development (Cambridge, England)\| PubMed ID: 27697904	2016
A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1. Science (New York, N.Y.)\| PubMed ID: 27846469	2016
An LHX1-Regulated Transcriptional Network Controls Sleep/Wake Coupling and Thermal Resistance of the Central Circadian Clockworks. Current biology : CB\| PubMed ID: 28017605	2017
The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states. Scientific reports\| PubMed ID: 28054653	2017
Global Analysis of SUMO-Binding Proteins Identifies SUMOylation as a Key Regulator of the INO80 Chromatin Remodeling Complex. Molecular & cellular proteomics : MCP\| PubMed ID: 28254775	2017
Assessing the model transferability for prediction of transcription factor binding sites based on chromatin accessibility. BMC bioinformatics\| PubMed ID: 28750606	2017
Understanding the Role of lncRNAs in Nervous System Development. Advances in experimental medicine and biology\| PubMed ID: 28815543	2017
Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep. Nature\| PubMed ID: 28847002	2017
Pax6 is essential for the generation of late-born retinal neurons and for inhibition of photoreceptor-fate during late stages of retinogenesis. Developmental biology\| PubMed ID: 28993200	2017
In Vivo Electroporation of Developing Mouse Retina. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 29188509	2018
Global Identification of Small Ubiquitin-related Modifier (SUMO) Substrates Reveals Crosstalk between SUMOylation and Phosphorylation Promotes Cell Migration. Molecular & cellular proteomics : MCP\| PubMed ID: 29438996	2018
Regulation and function of neurogenesis in the adult mammalian hypothalamus. Progress in neurobiology\| PubMed ID: 29631023	2018
ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration. Nature communications\| PubMed ID: 29636475	2018
A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nature methods\| PubMed ID: 29638227	2018
Ldb1- and Rnf12-dependent regulation of Lhx2 controls the relative balance between neurogenesis and gliogenesis in the retina. Development (Cambridge, England)\| PubMed ID: 29650591	2018
Foxd1 is required for terminal differentiation of anterior hypothalamic neuronal subtypes. Developmental biology\| PubMed ID: 29679559	2018
Antibody Specificity Profiling Using Protein Microarrays. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 29714021	2018
Asymmetric vasopressin signaling spatially organizes the master circadian clock. The Journal of comparative neurology\| PubMed ID: 29931690	2018
Canonical Wnt signaling regulates patterning, differentiation and nucleogenesis in mouse hypothalamus and prethalamus. Developmental biology\| PubMed ID: 30063881	2018
Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth. Life science alliance\| PubMed ID: 30456390	2018
Conditional deletion of Des1 in the mouse retina does not impair the visual cycle in cones. FASEB journal : official publication of the Federation of American Societies for Experimental Biology\| PubMed ID: 30645148	2019
Epigenomic profiling of retinal progenitors reveals LHX2 is required for developmental regulation of open chromatin. Communications biology\| PubMed ID: 31044167	2019
The selective estrogen receptor modulator raloxifene mitigates the effect of all--retinal toxicity in photoreceptor degeneration. The Journal of biological chemistry\| PubMed ID: 31073029	2019
Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification. Neuron\| PubMed ID: 31128945	2019
Reactive microglia and IL1β/IL-1R1-signaling mediate neuroprotection in excitotoxin-damaged mouse retina. Journal of neuroinflammation\| PubMed ID: 31170999	2019
Matrix-metalloproteinase expression and gelatinase activity in the avian retina and their influence on Müller glia proliferation. Experimental neurology\| PubMed ID: 31251936	2019
Global Analysis of Intercellular Homeodomain Protein Transfer. Cell reports\| PubMed ID: 31315049	2019
PanoView: An iterative clustering method for single-cell RNA sequencing data. PLoS computational biology\| PubMed ID: 31469823	2019
Clarin-1 expression in adult mouse and human retina highlights a role of Müller glia in Usher syndrome. The Journal of pathology\| PubMed ID: 31625146	2020
Photic generation of 11--retinal in bovine retinal pigment epithelium. The Journal of biological chemistry\| PubMed ID: 31694912	2019
ASCOT identifies key regulators of neuronal subtype-specific splicing. Nature communications\| PubMed ID: 31919425	2020
Tanycyte ablation in the arcuate nucleus and median eminence increases obesity susceptibility by increasing body fat content in male mice. Glia\| PubMed ID: 32173924	2020
NF-κB signaling regulates the formation of proliferating Müller glia-derived progenitor cells in the avian retina. Development (Cambridge, England)\| PubMed ID: 32291273	2020
Single-Cell Analysis of Human Retina Identifies Evolutionarily Conserved and Species-Specific Mechanisms Controlling Development. Developmental cell\| PubMed ID: 32386599	2020
Epigenetic hallmarks of age-related macular degeneration are recapitulated in a photosensitive mouse model. Human molecular genetics\| PubMed ID: 32691052	2020
The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development. Nature communications\| PubMed ID: 32868762	2020
Zeb2 regulates the balance between retinal interneurons and Müller glia by inhibition of BMP-Smad signaling. Developmental biology\| PubMed ID: 32950463	2020
Gene regulatory networks controlling vertebrate retinal regeneration. Science (New York, N.Y.)\| PubMed ID: 33004674	2020
Gene regulatory networks controlling differentiation, survival, and diversification of hypothalamic Lhx6-expressing GABAergic neurons. Communications biology\| PubMed ID: 33479483	2021
Turning lead into gold: reprogramming retinal cells to cure blindness. The Journal of clinical investigation\| PubMed ID: 33529169	2021
Temperature and species-dependent regulation of browning in retrobulbar fat. Scientific reports\| PubMed ID: 33542375	2021
Midkine is neuroprotective and influences glial reactivity and the formation of Müller glia-derived progenitor cells in chick and mouse retinas. Glia\| PubMed ID: 33569849	2021