Changwon Kho
Cardiovascular Research Center
Icahn School of Medicine at Mount Sinai
Chang Won is an Assistant Professor of Department of Medicine and Division of Cardiology at the Icahn School of Medicine at Mount Sinai, New York since 2015. In the last decade, his research has been focused on identifying and characterizing novel molecular pathways in heart failure. One area of particular interest to him is the role of post-translational modification of key proteins involved in cardiac dysfunction. He designed a multi-faceted approach to profile proteins in cardiomyocytes that interact with sarcoplasmic reticulum calcium ATPase (SERCA2a) pump. His efforts have led to the identification of Small Ubiquitin-like Modifier type 1 (SUMO1) as a potentially important target for heart failure therapy.
Atrial stretch and arrhythmia after myocardial infarction.
Aging 12, 2018 | Pubmed ID: 30594913
Experimental models of cardiac physiology and pathology.
Heart failure reviews 07, 2019 | Pubmed ID: 30666533
SUMO-1 gene transfer improves cardiac function in a large-animal model of heart failure.
Science translational medicine Nov, 2013 | Pubmed ID: 24225946
Inhibition of miR-25 improves cardiac contractility in the failing heart.
Nature Mar, 2014 | Pubmed ID: 24670661
The role of SUMO-1 in cardiac oxidative stress and hypertrophy.
Antioxidants & redox signaling Nov, 2014 | Pubmed ID: 24893265
Stem cell factor gene transfer improves cardiac function after myocardial infarction in swine.
Circulation. Heart failure Jan, 2015 | Pubmed ID: 25342737
Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure.
Nature communications Jun, 2015 | Pubmed ID: 26068603
Post-translational Modifications in Heart Failure: Small Changes, Big Impact.
Heart, lung & circulation Apr, 2016 | Pubmed ID: 26795636
Cardiac Stim1 Silencing Impairs Adaptive Hypertrophy and Promotes Heart Failure Through Inactivation of mTORC2/Akt Signaling.
Circulation Apr, 2016 | Pubmed ID: 26936863
Intratracheal Gene Delivery of SERCA2a Ameliorates Chronic Post-Capillary Pulmonary Hypertension: A Large Animal Model.
Journal of the American College of Cardiology 05, 2016 | Pubmed ID: 27126531
Matricellular Protein CCN5 Reverses Established Cardiac Fibrosis.
Journal of the American College of Cardiology 04, 2016 | Pubmed ID: 27150688
CXCR4 and CXCR7 play distinct roles in cardiac lineage specification and pharmacologic β-adrenergic response.
Stem cell research 08, 2017 | Pubmed ID: 28711757
Protein Phosphatase Inhibitor-1 Gene Therapy in a Swine Model of Nonischemic Heart Failure.
Journal of the American College of Cardiology Oct, 2017 | Pubmed ID: 28958332
miR-25 Tough Decoy Enhances Cardiac Function in Heart Failure.
Molecular therapy : the journal of the American Society of Gene Therapy 03, 2018 | Pubmed ID: 29273502
Measuring Cardiomyocyte Contractility and Calcium Handling In Vitro.
Methods in molecular biology (Clifton, N.J.) , 2018 | Pubmed ID: 29987813
Acute Left Ventricular Unloading Reduces Atrial Stretch and Inhibits Atrial Arrhythmias.
Journal of the American College of Cardiology 08, 2018 | Pubmed ID: 30092950
miR-146a Suppresses SUMO1 Expression and Induces Cardiac Dysfunction in Maladaptive Hypertrophy.
Circulation research 08, 2018 | Pubmed ID: 30355233
Role of the PRC2-Six1-miR-25 signaling axis in heart failure.
Journal of molecular and cellular cardiology Apr, 2019 | Pubmed ID: 30771307
Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca-ATPase in Heart Failure.
Circulation research 04, 2019 | Pubmed ID: 30786847
Cross-communication between fibroblasts and cardiomyocytes.
Non-coding RNA investigation Mar, 2019 | Pubmed ID: 31008445
Cardioprotective role of APIP in myocardial infarction through ADORA2B.
Cell death & disease Jul, 2019 | Pubmed ID: 31263105
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