Department of Molecular Physiology and Biophysics,
Vanderbilt Mouse Metabolic Phenotyping Center
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Prior exercise and the response to insulin-induced hypoglycemia in the dog.
American journal of physiology. Endocrinology and metabolism May, 2002 | Pubmed ID: 11934679
Prevention of overt hypoglycemia during exercise: stimulation of endogenous glucose production independent of hepatic catecholamine action and changes in pancreatic hormone concentration.
Diabetes May, 2002 | Pubmed ID: 11978626
Contrasting effects of exercise and NOS inhibition on tissue-specific fatty acid and glucose uptake in mice.
American journal of physiology. Endocrinology and metabolism Jul, 2002 | Pubmed ID: 12067851
Transporter-mediated absorption is the primary route of entry and is required for passive absorption of intestinal glucose into the blood of conscious dogs.
The Journal of nutrition Jul, 2002 | Pubmed ID: 12097672
Fiber type-specific determinants of Vmax for insulin-stimulated muscle glucose uptake in vivo.
American journal of physiology. Endocrinology and metabolism Mar, 2003 | Pubmed ID: 12556351
Prior exercise enhances passive absorption of intraduodenal glucose.
Journal of applied physiology (Bethesda, Md. : 1985) Sep, 2003 | Pubmed ID: 12740315
Effect of antecedent hypoglycemia on counterregulatory responses to subsequent euglycemic exercise in type 1 diabetes.
Diabetes Jul, 2003 | Pubmed ID: 12829644
Hexokinase II partial knockout impairs exercise-stimulated glucose uptake in oxidative muscles of mice.
American journal of physiology. Endocrinology and metabolism Nov, 2003 | Pubmed ID: 12865258
Interaction of insulin and prior exercise in control of hepatic metabolism of a glucose load.
Diabetes Aug, 2003 | Pubmed ID: 12882903
Regulation of hepatic and peripheral glucose disposal.
Best practice & research. Clinical endocrinology & metabolism Sep, 2003 | Pubmed ID: 12962690
Distributed control of glucose uptake by working muscles of conscious mice: roles of transport and phosphorylation.
American journal of physiology. Endocrinology and metabolism Jan, 2004 | Pubmed ID: 13129858
Quinides of roasted coffee enhance insulin action in conscious rats.
The Journal of nutrition Nov, 2003 | Pubmed ID: 14608069
Suppression of endogenous glucose production by mild hyperinsulinemia during exercise is determined predominantly by portal venous insulin.
Diabetes Feb, 2004 | Pubmed ID: 14747277
Hexokinase II overexpression improves exercise-stimulated but not insulin-stimulated muscle glucose uptake in high-fat-fed C57BL/6J mice.
Diabetes Feb, 2004 | Pubmed ID: 14747279
Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1.
Diabetes Feb, 2004 | Pubmed ID: 14747283
Effect of sex on counterregulatory responses to exercise after antecedent hypoglycemia in type 1 diabetes.
American journal of physiology. Endocrinology and metabolism Jul, 2004 | Pubmed ID: 14998785
Hepatic glucose autoregulation: responses to small, non-insulin-induced changes in arterial glucose.
American journal of physiology. Endocrinology and metabolism Aug, 2004 | Pubmed ID: 15053988
AMP kinase-induced skeletal muscle glucose but not long-chain fatty acid uptake is dependent on nitric oxide.
Diabetes Jun, 2004 | Pubmed ID: 15161745
AMPK stimulation increases LCFA but not glucose clearance in cardiac muscle in vivo.
American journal of physiology. Endocrinology and metabolism Nov, 2004 | Pubmed ID: 15265760
Regulation of insulin-stimulated muscle glucose uptake in the conscious mouse: role of glucose transport is dependent on glucose phosphorylation capacity.
Endocrinology Nov, 2004 | Pubmed ID: 15284204
Zonation of labeling of lipogenic acetyl-CoA across the liver: implications for studies of lipogenesis by mass isotopomer analysis.
The Journal of biological chemistry Oct, 2004 | Pubmed ID: 15284242
Portal venous hyperinsulinemia does not stimulate gut glucose absorption in the conscious dog.
Metabolism: clinical and experimental Oct, 2004 | Pubmed ID: 15375784
Physical activity/exercise and type 2 diabetes.
Diabetes care Oct, 2004 | Pubmed ID: 15451933
Heart-type fatty acid-binding protein reciprocally regulates glucose and fatty acid utilization during exercise.
American journal of physiology. Endocrinology and metabolism Feb, 2005 | Pubmed ID: 15454399
Control of exercise-stimulated muscle glucose uptake by GLUT4 is dependent on glucose phosphorylation capacity in the conscious mouse.
The Journal of biological chemistry Dec, 2004 | Pubmed ID: 15456776
Portal vein caffeine infusion enhances net hepatic glucose uptake during a glucose load in conscious dogs.
The Journal of nutrition Nov, 2004 | Pubmed ID: 15514273
Exercise-induced changes in insulin and glucagon are not required for enhanced hepatic glucose uptake after exercise but influence the fate of glucose within the liver.
Diabetes Dec, 2004 | Pubmed ID: 15561932
Control of muscle glucose uptake: test of the rate-limiting step paradigm in conscious, unrestrained mice.
The Journal of physiology Feb, 2005 | Pubmed ID: 15576451
Glucoregulation during and after exercise in health and insulin-dependent diabetes.
Exercise and sport sciences reviews Jan, 2005 | Pubmed ID: 15640716
5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside causes acute hepatic insulin resistance in vivo.
Diabetes Feb, 2005 | Pubmed ID: 15677492
Portal venous 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion overcomes hyperinsulinemic suppression of endogenous glucose output.
Diabetes Feb, 2005 | Pubmed ID: 15677495
Interaction of physiological mechanisms in control of muscle glucose uptake.
Clinical and experimental pharmacology & physiology Apr, 2005 | Pubmed ID: 15810999
Hexokinase II protein content is a determinant of exercise endurance capacity in the mouse.
The Journal of physiology Jul, 2005 | Pubmed ID: 15878951
5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside renders glucose output by the liver of the dog insensitive to a pharmacological increment in insulin.
American journal of physiology. Endocrinology and metabolism Dec, 2005 | Pubmed ID: 16046457
Mobilization of glucose from the liver during exercise and replenishment afterward.
Canadian journal of applied physiology = Revue canadienne de physiologie appliquée Jun, 2005 | Pubmed ID: 16129894
Plasminogen activator inhibitor-1 modulates adipocyte differentiation.
American journal of physiology. Endocrinology and metabolism Jan, 2006 | Pubmed ID: 16144810
Energy state of the liver during short-term and exhaustive exercise in C57BL/6J mice.
American journal of physiology. Endocrinology and metabolism Mar, 2006 | Pubmed ID: 16219665
Insulin secretion in the conscious mouse is biphasic and pulsatile.
American journal of physiology. Endocrinology and metabolism Mar, 2006 | Pubmed ID: 16249252
Partial gene deletion of heart-type fatty acid-binding protein limits the severity of dietary-induced insulin resistance.
Diabetes Nov, 2005 | Pubmed ID: 16249436
Individual mice can be distinguished by the period of their islet calcium oscillations: is there an intrinsic islet period that is imprinted in vivo?
Diabetes Dec, 2005 | Pubmed ID: 16306370
Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse.
Diabetes Feb, 2006 | Pubmed ID: 16443772
Physical activity/exercise and type 2 diabetes: a consensus statement from the American Diabetes Association.
Diabetes care Jun, 2006 | Pubmed ID: 16732040
Point-Counterpoint: Glucose phosphorylation is/is not a significant barrier to muscle glucose uptake by the working muscle.
Journal of applied physiology (Bethesda, Md. : 1985) Dec, 2006 | Pubmed ID: 17106068
Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice.
Diabetes Apr, 2007 | Pubmed ID: 17229936
Glucose kinetics and exercise tolerance in mice lacking the GLUT4 glucose transporter.
The Journal of physiology Jul, 2007 | Pubmed ID: 17495042
Phosphorylation barriers to skeletal and cardiac muscle glucose uptakes in high-fat fed mice: studies in mice with a 50% reduction of hexokinase II.
Diabetes Oct, 2007 | Pubmed ID: 17639019
Insulin action in the double incretin receptor knockout mouse.
Diabetes Feb, 2008 | Pubmed ID: 17977951
Glucose metabolism in vivo in four commonly used inbred mouse strains.
Diabetes Jul, 2008 | Pubmed ID: 18398139
Long chain fatty acid uptake in vivo: comparison of [125I]-BMIPP and [3H]-bromopalmitate.
Lipids Aug, 2008 | Pubmed ID: 18481132
Markers of glycemic control in the mouse: comparisons of 6-h- and overnight-fasted blood glucoses to Hb A1c.
American journal of physiology. Endocrinology and metabolism Oct, 2008 | Pubmed ID: 18664598
Metabolic implications of reduced heart-type fatty acid binding protein in insulin resistant cardiac muscle.
Biochimica et biophysica acta Oct, 2008 | Pubmed ID: 18692568
Four grams of glucose.
American journal of physiology. Endocrinology and metabolism Jan, 2009 | Pubmed ID: 18840763
The glucagon-like peptide-1 receptor regulates endogenous glucose production and muscle glucose uptake independent of its incretin action.
Endocrinology Mar, 2009 | Pubmed ID: 19008308
Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans.
The Journal of clinical investigation Mar, 2009 | Pubmed ID: 19188683
Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity.
Endocrinology Sep, 2009 | Pubmed ID: 19470704
Skeletal muscle AMP-activated protein kinase is essential for the metabolic response to exercise in vivo.
The Journal of biological chemistry Sep, 2009 | Pubmed ID: 19525228
NIH experiment in centralized mouse phenotyping: the Vanderbilt experience and recommendations for evaluating glucose homeostasis in the mouse.
American journal of physiology. Endocrinology and metabolism Oct, 2009 | Pubmed ID: 19638507
Hepatic energy state is regulated by glucagon receptor signaling in mice.
The Journal of clinical investigation Aug, 2009 | Pubmed ID: 19662685
Lost in translation.
Diabetes Sep, 2009 | Pubmed ID: 19720822
Circadian clock gene Bmal1 is not essential; functional replacement with its paralog, Bmal2.
Current biology : CB Feb, 2010 | Pubmed ID: 20153195
Endothelial nitric oxide synthase is central to skeletal muscle metabolic regulation and enzymatic signaling during exercise in vivo.
American journal of physiology. Regulatory, integrative and comparative physiology May, 2010 | Pubmed ID: 20200137
Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARalpha and FGF21 transcripts in vivo.
American journal of physiology. Endocrinology and metabolism Oct, 2010 | Pubmed ID: 20663988
Glucagon-like peptide-1 receptor knockout mice are protected from high-fat diet-induced insulin resistance.
Endocrinology Oct, 2010 | Pubmed ID: 20685876
Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice.
Disease models & mechanisms Sep-Oct, 2010 | Pubmed ID: 20713647
The physiological regulation of glucose flux into muscle in vivo.
The Journal of experimental biology Jan, 2011 | Pubmed ID: 21177945
Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking.
Cell metabolism Jan, 2011 | Pubmed ID: 21195350
Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis.
The Biochemical journal Mar, 2011 | Pubmed ID: 21204784
Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice.
Diabetes Feb, 2011 | Pubmed ID: 21270253
Assessment of different bariatric surgeries in the treatment of obesity and insulin resistance in mice.
Annals of surgery Jul, 2011 | Pubmed ID: 21522012
Hepatic glucagon action is essential for exercise-induced reversal of mouse fatty liver.
Diabetes Nov, 2011 | Pubmed ID: 21885872
Mesenchymal stem cell transplantation for the infarcted heart: a role in minimizing abnormalities in cardiac-specific energy metabolism.
American journal of physiology. Endocrinology and metabolism Jan, 2012 | Pubmed ID: 21971524
Overproduction of angiotensinogen from adipose tissue induces adipose inflammation, glucose intolerance, and insulin resistance.
Obesity (Silver Spring, Md.) Jan, 2012 | Pubmed ID: 21979391
Disassociation of Muscle Insulin Signaling and Insulin-Stimulated Glucose Uptake during Endotoxemia.
PloS one , 2012 | Pubmed ID: 22276152
Julio E. Ayala1,
Deanna P. Bracy2,3,
Carlo Malabanan3,
Freyja D. James2,3,
Tasneem Ansari3,
Patrick T. Fueger4,
Owen P. McGuinness2,3,
David H. Wasserman2,3
1Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute at Lake Nona,
2Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine,
3Vanderbilt Mouse Metabolic Phenotyping Center, Vanderbilt University School of Medicine,
4Department of Pediatrics and Cellular and Integrative Physiology, Indiana University School of Medicine
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