Keiyo Takubo

Department of Stem Cell Biology, National Center for Global Health and Medicine

Affiliated withNational Center for Global Health and Medicine

Research Area

Bioengineering

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2021

Other Publications

Article	Year
Premeiotic germ cell defect in seminiferous tubules of Atm-null testis. Biochemical and biophysical research communications\| PubMed ID: 17097049	2006
Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell-cycle arrest. Cell stem cell\| PubMed ID: 18371438	2008
Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell stem cell\| PubMed ID: 20804974	2010
Roles of the hypoxia response system in hematopoietic and leukemic stem cells. International journal of hematology\| PubMed ID: 22539363	2012
Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. Cell stem cell\| PubMed ID: 23290136	2013
Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING. Cell reports\| PubMed ID: 25843711	2015
Integrative Analysis of the Acquisition of Pluripotency in PGCs Reveals the Mutually Exclusive Roles of Blimp-1 and AKT Signaling. Stem cell reports\| PubMed ID: 26050930	2015
ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function. Scientific reports\| PubMed ID: 26242473	2015
[Metabolic regulation of stem cells]. [Rinsho ketsueki] The Japanese journal of clinical hematology\| PubMed ID: 26458425	2015
Hypoxia regulates the hematopoietic stem cell niche. Pflugers Archiv : European journal of physiology\| PubMed ID: 26490456	2016
Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration. Arthritis research & therapy\| PubMed ID: 26542776	2015
CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow. The Journal of experimental medicine\| PubMed ID: 26552707	2015
How hematopoietic stem/progenitors and their niche sense and respond to infectious stress. Experimental hematology\| PubMed ID: 26646990	2016
Angiopoietin-like Protein 2 Is a Multistep Regulator of Inflammatory Neovascularization in a Murine Model of Age-related Macular Degeneration. The Journal of biological chemistry\| PubMed ID: 26839315	2016
Loss of Folliculin Disrupts Hematopoietic Stem Cell Quiescence and Homeostasis Resulting in Bone Marrow Failure. Stem cells (Dayton, Ohio)\| PubMed ID: 27095138	2016
Chordoma-derived cell line U-CH1-N recapitulates the biological properties of notochordal nucleus pulposus cells. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 27248133	2016
Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes. Blood\| PubMed ID: 27301860	2016
p38α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress. Cell stem cell\| PubMed ID: 27345838	2016
Maintenance of the functional integrity of mouse hematopoiesis by EED and promotion of leukemogenesis by EED haploinsufficiency. Scientific reports\| PubMed ID: 27432459	2016
Acquired expression of in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia. Blood\| PubMed ID: 28209720	2017
[Stress response mechanism in hematopoietic stem cells.] Clinical calcium\| PubMed ID: 28536320	2017
Metabolic regulation of hematopoietic and leukemic stem/progenitor cells under homeostatic and stress conditions. International journal of hematology\| PubMed ID: 28540498	2017
Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis. The Journal of biological chemistry\| PubMed ID: 28578315	2017
Abnormal hematopoiesis and hematopoietic stem cell niche. [Rinsho ketsueki] The Japanese journal of clinical hematology\| PubMed ID: 28978823	2017
Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival. Nature communications\| PubMed ID: 29674746	2018
Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells. Experimental hematology\| PubMed ID: 29709619	2018
Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research\| PubMed ID: 29893999	2018
Potential involvement of semaphorin 3A in maintaining intervertebral disc tissue homeostasis. Journal of orthopaedic research : official publication of the Orthopaedic Research Society\| PubMed ID: 30816586	2019
ATP turnover and glucose dependency in hematopoietic stem/progenitor cells are increased by proliferation and differentiation. Biochemical and biophysical research communications\| PubMed ID: 31030941	2019
Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo. Cell reports\| PubMed ID: 31269436	2019
Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses. Cell\| PubMed ID: 31442401	2019
Type I Interferon Delivery by iPSC-Derived Myeloid Cells Elicits Antitumor Immunity via XCR1 Dendritic Cells. Cell reports\| PubMed ID: 31577946	2019
Discrimination of Dormant and Active Hematopoietic Stem Cells by G Marker Reveals Dormancy Regulation by Cytoplasmic Calcium. Cell reports\| PubMed ID: 31851939	2019
Identification and local manipulation of bone marrow vasculature during intravital imaging. Scientific reports\| PubMed ID: 32286470	2020
Phosphoglycerate Mutase Cooperates with Chk1 Kinase to Regulate Glycolysis. iScience\| PubMed ID: 32634742	2020
Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection. PLoS biology\| PubMed ID: 32991574	2020
Detection of residual disease in chronic myeloid leukemia utilizing genomic next generation sequencing reveals persistence of differentiated Ph B cells but not bone marrow stem/progenitors. Leukemia & lymphoma\| PubMed ID: 33106061	2021
Protocol for the Maintenance of Quiescent Murine Hematopoietic Stem Cells. STAR protocols\| PubMed ID: 33111112	2020
UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes. Blood\| PubMed ID: 33174606	2021
OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy. Cell reports\| PubMed ID: 33406421	2021
p38α plays differential roles in hematopoietic stem cell activity dependent on aging contexts. The Journal of biological chemistry\| PubMed ID: 33745970	2021
Characterization of genetically modified mice for phosphoglycerate mutase, a vitally-essential enzyme in glycolysis. PloS one\| PubMed ID: 33914812	2021