Keiyo Takubo

Premeiotic germ cell defect in seminiferous tubules of Atm-null testis.

Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell-cycle arrest.

Regulation of the HIF-1alpha level is essential for hematopoietic stem cells.

Roles of the hypoxia response system in hematopoietic and leukemic stem cells.

Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells.

Bacterial c-di-GMP affects hematopoietic stem/progenitors and their niches through STING.

Integrative Analysis of the Acquisition of Pluripotency in PGCs Reveals the Mutually Exclusive Roles of Blimp-1 and AKT Signaling.

ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function.

[Metabolic regulation of stem cells].

Hypoxia regulates the hematopoietic stem cell niche.

Excessive reactive oxygen species are therapeutic targets for intervertebral disc degeneration.

CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow.

How hematopoietic stem/progenitors and their niche sense and respond to infectious stress.

Angiopoietin-like Protein 2 Is a Multistep Regulator of Inflammatory Neovascularization in a Murine Model of Age-related Macular Degeneration.

Loss of Folliculin Disrupts Hematopoietic Stem Cell Quiescence and Homeostasis Resulting in Bone Marrow Failure.

Chordoma-derived cell line U-CH1-N recapitulates the biological properties of notochordal nucleus pulposus cells.

Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes.

p38α Activates Purine Metabolism to Initiate Hematopoietic Stem/Progenitor Cell Cycling in Response to Stress.

Maintenance of the functional integrity of mouse hematopoiesis by EED and promotion of leukemogenesis by EED haploinsufficiency.

Acquired expression of in mice induces dysplastic myelopoiesis mimicking chronic myelomonocytic leukemia.

[Stress response mechanism in hematopoietic stem cells.]

Metabolic regulation of hematopoietic and leukemic stem/progenitor cells under homeostatic and stress conditions.

Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis.

Abnormal hematopoiesis and hematopoietic stem cell niche.

Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival.

Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells.

Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation.

Potential involvement of semaphorin 3A in maintaining intervertebral disc tissue homeostasis.

ATP turnover and glucose dependency in hematopoietic stem/progenitor cells are increased by proliferation and differentiation.

Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo.

Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses.

Type I Interferon Delivery by iPSC-Derived Myeloid Cells Elicits Antitumor Immunity via XCR1 Dendritic Cells.

Discrimination of Dormant and Active Hematopoietic Stem Cells by G Marker Reveals Dormancy Regulation by Cytoplasmic Calcium.

Identification and local manipulation of bone marrow vasculature during intravital imaging.

Phosphoglycerate Mutase Cooperates with Chk1 Kinase to Regulate Glycolysis.

Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection.

Detection of residual disease in chronic myeloid leukemia utilizing genomic next generation sequencing reveals persistence of differentiated Ph B cells but not bone marrow stem/progenitors.

Protocol for the Maintenance of Quiescent Murine Hematopoietic Stem Cells.

UTX maintains the functional integrity of the murine hematopoietic system by globally regulating aging-associated genes.

OGT Regulates Hematopoietic Stem Cell Maintenance via PINK1-Dependent Mitophagy.

p38α plays differential roles in hematopoietic stem cell activity dependent on aging contexts.

Characterization of genetically modified mice for phosphoglycerate mutase, a vitally-essential enzyme in glycolysis.