Frank Sobott

School of Molecular and Cellular Biology, University of Leeds

Research Area

Biochemistry

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2021

Other Publications

Article	Year
Combining density functional theory (DFT) and collision cross-section (CCS) calculations to analyze the gas-phase behaviour of small molecules and their protonation site isomers. The Analyst\| PubMed ID: 27264846	2016
Opposite Structural Effects of Epigallocatechin-3-gallate and Dopamine Binding to α-Synuclein. Analytical chemistry\| PubMed ID: 27467405	2016
Conformational Space and Stability of ETD Charge Reduction Products of Ubiquitin. Journal of the American Society for Mass Spectrometry\| PubMed ID: 27495285	2017
Proton Dynamics in Protein Mass Spectrometry. The journal of physical chemistry letters\| PubMed ID: 28207277	2017
Analyzing complex mixtures of drug-like molecules: Ion mobility as an adjunct to existing liquid chromatography-(tandem) mass spectrometry methods. Journal of chromatography. A\| PubMed ID: 28228233	2017
Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics. Molecular cell\| PubMed ID: 28306503	2017
AtaT blocks translation initiation by N-acetylation of the initiator tRNA. Nature chemical biology\| PubMed ID: 28369041	2017
Specific sequences in the N-terminal domain of human small heat-shock protein HSPB6 dictate preferential hetero-oligomerization with the orthologue HSPB1. The Journal of biological chemistry\| PubMed ID: 28487364	2017
Native Mass Spectrometry for the Characterization of Structure and Interactions of Membrane Proteins. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 28755371	2017
Apparent activation energies of protein-protein complex dissociation in the gas-phase determined by electrospray mass spectrometry. Analytical and bioanalytical chemistry\| PubMed ID: 28900708	2017
Advances in native high-performance liquid chromatography and intact mass spectrometry for the characterization of biopharmaceutical products. Journal of separation science\| PubMed ID: 28990739	2018
A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover. Nature communications\| PubMed ID: 29044096	2017
Analysis of the natively unstructured RNA/protein-recognition core in the Escherichia coli RNA degradosome and its interactions with regulatory RNA/Hfq complexes. Nucleic acids research\| PubMed ID: 29136196	2018
Evaluation of ion mobility for the separation of glycoconjugate isomers due to different types of sialic acid linkage, at the intact glycoprotein, glycopeptide and glycan level. Journal of proteomics\| PubMed ID: 29197583	2018
The structural basis for dynamic DNA binding and bridging interactions which condense the bacterial centromere. eLife\| PubMed ID: 29244022	2017
Fixed-Charge Trimethyl Pyrilium Modification for Enabling Enhanced Top-Down Mass Spectrometry Sequencing of Intact Protein Complexes. Analytical chemistry\| PubMed ID: 29360341	2018
Radical solutions: Principles and application of electron-based dissociation in mass spectrometry-based analysis of protein structure. Mass spectrometry reviews\| PubMed ID: 29425406	2018
Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors. Science advances\| PubMed ID: 29546243	2018
The effect of reactive oxygen and nitrogen species on the structure of cytoglobin: A potential tumor suppressor. Redox biology\| PubMed ID: 30081385	2018
Editorial and Review: 30th ASMS Sanibel Conference on Mass Spectrometry-Computational Modelling in Mass Spectrometry and Ion Mobility: Methods for Ion Structure and Reactivity Determination. Journal of the American Society for Mass Spectrometry\| PubMed ID: 30397862	2018
masstodon: A Tool for Assigning Peaks and Modeling Electron Transfer Reactions in Top-Down Mass Spectrometry. Analytical chemistry\| PubMed ID: 30608646	2019
Recommendations for reporting ion mobility Mass Spectrometry measurements. Mass spectrometry reviews\| PubMed ID: 30707468	2019
Methionine oxidation in α-synuclein inhibits its propensity for ordered secondary structure. The Journal of biological chemistry\| PubMed ID: 30755483	2019
A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT. Nature communications\| PubMed ID: 30814507	2019
Cyclized NDGA modifies dynamic α-synuclein monomers preventing aggregation and toxicity. Scientific reports\| PubMed ID: 30814575	2019
Thermodynamic Stability of the Transcription Regulator PaaR2 from Escherichia coli O157:H7. Biophysical journal\| PubMed ID: 30979547	2019
First Community-Wide, Comparative Cross-Linking Mass Spectrometry Study. Analytical chemistry\| PubMed ID: 31045356	2019
Native Ion Mobility-Mass Spectrometry Reveals the Formation of β-Barrel Shaped Amyloid-β Hexamers in a Membrane-Mimicking Environment. Journal of the American Chemical Society\| PubMed ID: 31141355	2019
MIND: A Double-Linear Model To Accurately Determine Monoisotopic Precursor Mass in High-Resolution Top-Down Proteomics. Analytical chemistry\| PubMed ID: 31283196	2019
Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP. Nature communications\| PubMed ID: 31320618	2019
How metal cofactors drive dimer-dodecamer transition of the M42 aminopeptidase TmPep1050 of . The Journal of biological chemistry\| PubMed ID: 31611236	2019
A cryo-EM grid preparation device for time-resolved structural studies. IUCrJ\| PubMed ID: 31709058	2019
Enhanced oligomerization of full-length RAGE by synergy of the interaction of its domains. Scientific reports\| PubMed ID: 31889156	2019
The Escherichia coli RnlA-RnlB toxin-antitoxin complex: production, characterization and crystallization. Acta crystallographica. Section F, Structural biology communications\| PubMed ID: 31929184	2020
Styrene maleic-acid lipid particles (SMALPs) into detergent or amphipols: An exchange protocol for membrane protein characterisation. Biochimica et biophysica acta. Biomembranes\| PubMed ID: 31945320	2020
Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies. The Biochemical journal\| PubMed ID: 32167135	2020
Sample deposition onto cryo-EM grids: from sprays to jets and back. Acta crystallographica. Section D, Structural biology\| PubMed ID: 32254058	2020
Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity. Nature communications\| PubMed ID: 32499486	2020
Software Requirements for the Analysis and Interpretation of Native Ion Mobility Mass Spectrometry Data. Analytical chemistry\| PubMed ID: 32649184	2020
Computational Strategies and Challenges for Using Native Ion Mobility Mass Spectrometry in Biophysics and Structural Biology. Analytical chemistry\| PubMed ID: 32667808	2020
M42 aminopeptidase catalytic site: the structural and functional role of a strictly conserved aspartate residue. Proteins\| PubMed ID: 32673419	2020
Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry. Journal of the American Society for Mass Spectrometry\| PubMed ID: 32812765	2020
Need for Speed: Examining Protein Behavior during CryoEM Grid Preparation at Different Timescales. Structure (London, England : 1993)\| PubMed ID: 32814033	2020
Metal ions shape α-synuclein. Scientific reports\| PubMed ID: 33004902	2020
Toward Increased Reliability, Transparency, and Accessibility in Cross-linking Mass Spectrometry. Structure (London, England : 1993)\| PubMed ID: 33065067	2020
Effects of Detergent on α-Synuclein Structure. A Native MS-Ion Mobility Study. International journal of molecular sciences\| PubMed ID: 33114222	2020
Do Aptamers Always Bind? The Need for a Multifaceted Analytical Approach When Demonstrating Binding Affinity between Aptamer and Low Molecular Weight Compounds. Journal of the American Chemical Society\| PubMed ID: 33166132	2020
Further insights from structural mass spectrometry into endocytosis adaptor protein assemblies. International journal of mass spectrometry\| PubMed ID: 33244295	2020
Aptamer-ligand recognition studied by native ion mobility-mass spectrometry. Talanta\| PubMed ID: 33379118	2021
Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation. Journal of molecular biology\| PubMed ID: 33422522	2021
Cryo-EM structure of human mitochondrial HSPD1. iScience\| PubMed ID: 33506187	2021
Unveiling the binding mode of perfluorooctanoic acid to human serum albumin. Protein science : a publication of the Protein Society\| PubMed ID: 33550662	2021
Interrogating Membrane Protein Structure and Lipid Interactions by Native Mass Spectrometry. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 33582995	2020
Brazilin Removes Toxic Alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium. Journal of molecular biology\| PubMed ID: 33610557	2021
A model of full-length RAGE in complex with S100B. Structure (London, England : 1993)\| PubMed ID: 33887170	2021
Structural modeling of a novel membrane-bound globin-coupled sensor in . Computational and structural biotechnology journal\| PubMed ID: 33995893	2021
Structure of the endocytic adaptor complex reveals the basis for efficient membrane anchoring during clathrin-mediated endocytosis. Nature communications\| PubMed ID: 34001871	2021
Entropic pressure controls the oligomerization of the Vibrio cholerae ParD2 antitoxin. Acta crystallographica. Section D, Structural biology\| PubMed ID: 34196617	2021
Profiling Dopamine-Induced Oxidized Proteoforms of β-synuclein by Top-Down Mass Spectrometry. Antioxidants (Basel, Switzerland)\| PubMed ID: 34206096	2021
Analysis of the PcrA-RNA polymerase complex reveals a helicase interaction motif and a role for PcrA/UvrD helicase in the suppression of R-loops. eLife\| PubMed ID: 34279225	2021
On-grid and in-flow mixing for time-resolved cryo-EM. Acta crystallographica. Section D, Structural biology\| PubMed ID: 34605427	2021
Nanobody-aided crystallization of the transcription regulator PaaR2 from Escherichia coli O157:H7. Acta crystallographica. Section F, Structural biology communications\| PubMed ID: 34605442	2021