Laboratory of Pharmaceutical Pharmacology
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Cardioprotective effects of N-hydroxyguanidine PR5 in myocardial ischaemia and reperfusion in rats.
British journal of pharmacology Nov, 1999 | Pubmed ID: 10556947
Mildronate: cardioprotective action through carnitine-lowering effect.
Trends in cardiovascular medicine Aug, 2002 | Pubmed ID: 12242052
The methylester of gamma-butyrobetaine, but not gamma-butyrobetaine itself, induces muscarinic receptor-dependent vasodilatation.
Naunyn-Schmiedeberg's archives of pharmacology May, 2004 | Pubmed ID: 15060760
Investigations on the pharmacology of the cardioprotective guanidine ME10092.
Journal of cardiovascular pharmacology Aug, 2004 | Pubmed ID: 15243298
The differential influences of melanocortins on nociception in the formalin and tail flick tests.
Pharmacology, biochemistry, and behavior Oct, 2006 | Pubmed ID: 16970983
Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction.
Journal of cardiovascular pharmacology Dec, 2006 | Pubmed ID: 17204911
Comparative pharmacological activity of optical isomers of phenibut.
European journal of pharmacology Mar, 2008 | Pubmed ID: 18275958
Effect of inhibiting carnitine biosynthesis on male rat sexual performance.
Physiology & behavior Oct, 2008 | Pubmed ID: 18640137
Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart.
Life sciences Oct, 2008 | Pubmed ID: 18801379
Quantitative analysis of phenibut in rat brain tissue extracts by liquid chromatography-tandem mass spectrometry.
Biomedical chromatography : BMC Dec, 2008 | Pubmed ID: 19034959
Myocardial infarct size-limiting and anti-arrhythmic effects of mildronate orotate in the rat heart.
Cardiovascular drugs and therapy Aug, 2009 | Pubmed ID: 19536647
Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats.
British journal of pharmacology Aug, 2009 | Pubmed ID: 19594753
Effects of long-term mildronate treatment on cardiac and liver functions in rats.
Basic & clinical pharmacology & toxicology Dec, 2009 | Pubmed ID: 19663820
Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism.
Journal of enzyme inhibition and medicinal chemistry Dec, 2009 | Pubmed ID: 19912061
The anti-inflammatory and antinociceptive effects of NF-kappaB inhibitory guanidine derivative ME10092.
International immunopharmacology Apr, 2010 | Pubmed ID: 20074673
Mildronate exerts acute anticonvulsant and antihypnotic effects.
Behavioural pharmacology Sep, 2010 | Pubmed ID: 20661137
Flow cytometric analysis of glyoxalase-1 expression in human leukocytes.
Cell biochemistry and function Mar, 2011 | Pubmed ID: 21370249
Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats.
European journal of pharmacology May, 2011 | Pubmed ID: 21371472
Mildronate treatment improves functional recovery following middle cerebral artery occlusion in rats.
Behavioural brain research Sep, 2011 | Pubmed ID: 21420440
Investigation into stereoselective pharmacological activity of phenotropil.
Basic & clinical pharmacology & toxicology Nov, 2011 | Pubmed ID: 21689376
Mildronate treatment alters γ-butyrobetaine and l-carnitine concentrations in healthy volunteers.
The Journal of pharmacy and pharmacology Sep, 2011 | Pubmed ID: 21827492
Administration of L-carnitine and mildronate improves endothelial function and decreases mortality in hypertensive Dahl rats.
Pharmacological reports : PR , 2011 | Pubmed ID: 21857086
The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine.
Journal of cardiovascular pharmacology and therapeutics Jun, 2012 | Pubmed ID: 21903968
A short-term high-dose administration of sodium pivalate impairs pyruvate metabolism without affecting cardiac function.
Cardiovascular toxicology Dec, 2012 | Pubmed ID: 22539084
The sensorimotor and cognitive deficits in rats following 90- and 120-min transient occlusion of the middle cerebral artery.
Journal of neuroscience methods Jul, 2012 | Pubmed ID: 22640751
High L-carnitine concentrations do not prevent late diabetic complications in type 1 and 2 diabetic patients.
Nutrition research (New York, N.Y.) May, 2012 | Pubmed ID: 22652370
Glyoxalase 1 and glyoxalase 2 activities in blood and neuronal tissue samples from experimental animal models of obesity and type 2 diabetes mellitus.
The journal of physiological sciences : JPS Nov, 2012 | Pubmed ID: 22893478
Troubleshooting digital macro photography for image acquisition and the analysis of biological samples.
Journal of pharmacological and toxicological methods Mar-Apr, 2013 | Pubmed ID: 23202591
Association of reduced glyoxalase 1 activity and painful peripheral diabetic neuropathy in type 1 and 2 diabetes mellitus patients.
Journal of diabetes and its complications May-Jun, 2013 | Pubmed ID: 23351995
Activated peroxisomal fatty acid metabolism improves cardiac recovery in ischemia-reperfusion.
Naunyn-Schmiedeberg's archives of pharmacology Jun, 2013 | Pubmed ID: 23525500
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.
Bioorganic & medicinal chemistry May, 2013 | Pubmed ID: 23582449
Elevated vascular γ-butyrobetaine levels attenuate the development of high glucose-induced endothelial dysfunction.
Clinical and experimental pharmacology & physiology Aug, 2013 | Pubmed ID: 23710938
Meldonium decreases the diet-increased plasma levels of trimethylamine N-oxide, a metabolite associated with atherosclerosis.
Journal of clinical pharmacology Oct, 2013 | Pubmed ID: 23893520
The heart is better protected against myocardial infarction in the fed state compared to the fasted state.
Metabolism: clinical and experimental Jan, 2014 | Pubmed ID: 24140100
Mildronate, the inhibitor of L-carnitine transport, induces brain mitochondrial uncoupling and protects against anoxia-reoxygenation.
European journal of pharmacology Jan, 2014 | Pubmed ID: 24333219
Libiguins A and B: novel phragmalin limonoids isolated from Neobeguea mahafalensis causing profound enhancement of sexual activity.
Planta medica Mar, 2014 | Pubmed ID: 24549927
Magnesium nitrate attenuates blood pressure rise in SHR rats.
Magnesium research Jan-Mar, 2014 | Pubmed ID: 24827813
Selective inhibition of OCTN2 is more effective than inhibition of gamma-butyrobetaine dioxygenase to decrease the availability of l-carnitine and to reduce myocardial infarct size.
Pharmacological research Jul, 2014 | Pubmed ID: 24836867
Long-chain acylcarnitine content determines the pattern of energy metabolism in cardiac mitochondria.
Molecular and cellular biochemistry Oct, 2014 | Pubmed ID: 24878991
Acute anti-hyperglycaemic effects of an unripe apple preparation containing phlorizin in healthy volunteers: a preliminary study.
Journal of the science of food and agriculture Feb, 2015 | Pubmed ID: 24917557
A cross-sectional survey of urinary iodine status in Latvia.
Medicina (Kaunas, Lithuania) , 2014 | Pubmed ID: 25172607
Suppression of intestinal microbiota-dependent production of pro-atherogenic trimethylamine N-oxide by shifting L-carnitine microbial degradation.
Life sciences Nov, 2014 | Pubmed ID: 25301199
Determination of trimethylamine-N-oxide in combination with L-carnitine and γ-butyrobetaine in human plasma by UPLC/MS/MS.
Biomedical chromatography : BMC Nov, 2015 | Pubmed ID: 25873316
Methyl-γ-butyrobetaine decreases levels of acylcarnitines and attenuates the development of atherosclerosis.
Vascular pharmacology Sep, 2015 | Pubmed ID: 25989106
Structure and Function of CutC Choline Lyase from Human Microbiota Bacterium Klebsiella pneumoniae.
The Journal of biological chemistry Aug, 2015 | Pubmed ID: 26187464
R-phenibut binds to the α2-δ subunit of voltage-dependent calcium channels and exerts gabapentin-like anti-nociceptive effects.
Pharmacology, biochemistry, and behavior Oct, 2015 | Pubmed ID: 26234470
The neuroprotective effects of R-phenibut after focal cerebral ischemia.
Pharmacological research 11, 2016 | Pubmed ID: 26621244
Decreased acylcarnitine content improves insulin sensitivity in experimental mice models of insulin resistance.
Pharmacological research 11, 2016 | Pubmed ID: 26621248
Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity.
Pharmacological research 11, 2016 | Pubmed ID: 26850121
Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria.
The Biochemical journal 05, 2016 | Pubmed ID: 26936967
The unusual pharmacokinetics of meldonium: Implications for doping.
Pharmacological research Sep, 2016 | Pubmed ID: 27262679
Response to comment by Sergei V. Jargin: "Meldonium (Mildronate): primum nоn nocere".
Pharmacological research Dec, 2016 | Pubmed ID: 27725311
Carnitine and γ-Butyrobetaine Stimulate Elimination of Meldonium due to Competition for OCTN2-mediated Transport.
Basic & clinical pharmacology & toxicology May, 2017 | Pubmed ID: 27983775
Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria.
Toxicology letters Feb, 2017 | Pubmed ID: 28049038
Decrease in Long-Chain Acylcarnitine Tissue Content Determines the Duration of and Correlates with the Cardioprotective Effect of Methyl-GBB.
Basic & clinical pharmacology & toxicology Aug, 2017 | Pubmed ID: 28244203
The activity of selective sigma-1 receptor ligands in seizure models in vivo.
Behavioural brain research 06, 2017 | Pubmed ID: 28389336
S-phenylpiracetam, a selective DAT inhibitor, reduces body weight gain without influencing locomotor activity.
Pharmacology, biochemistry, and behavior 09, 2017 | Pubmed ID: 28743458
Acute and long-term administration of palmitoylcarnitine induces muscle-specific insulin resistance in mice.
BioFactors (Oxford, England) Sep, 2017 | Pubmed ID: 28759135
Denosumab-induced hypophosphataemia in a case of normocalcaemic primary hyperparathyroidism.
Internal medicine journal 08, 2017 | Pubmed ID: 28782221
Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues.
Scientific reports 12, 2017 | Pubmed ID: 29235526
Letter to the Editor: "Serum Carnitine Metabolites and Incident Type 2 Diabetes Mellitus in Patients With Suspected Stable Angina Pectoris".
The Journal of clinical endocrinology and metabolism 11, 2018 | Pubmed ID: 30124877
Efficacy of Proanthocyanidins from Root Extract in Reducing Viability While Preserving Oral Commensal .
Materials (Basel, Switzerland) Aug, 2018 | Pubmed ID: 30135370
Development of local strontium ranelate delivery systems and long term in vitro drug release studies in osteogenic medium.
Scientific reports 11, 2018 | Pubmed ID: 30425295
Mitochondrial Function in the Kidney and Heart, but Not the Brain, is Mainly Altered in an Experimental Model of Endotoxaemia.
Shock (Augusta, Ga.) 12, 2019 | Pubmed ID: 30640252
Dietary Polyphenols Targeting Arterial Stiffness: Interplay of Contributing Mechanisms and Gut Microbiome-Related Metabolism.
Nutrients Mar, 2019 | Pubmed ID: 30857217
Allosteric Modulators of Sigma-1 Receptor: A Review.
Frontiers in pharmacology , 2019 | Pubmed ID: 30941035
Total synthesis and evaluation of 8-deoxypumiliotoxin 193H.
Natural product research Feb, 2021 | Pubmed ID: 31264906
Effects of the N-methyl-d-aspartate receptor antagonist, MK-801, on spatial memory and influence of the route of administration.
Behavioural brain research 10, 2019 | Pubmed ID: 31276703
Skull Fractures Induce Neuroinflammation and Worsen Outcomes after Closed Head Injury in Mice.
Journal of neurotrauma 01, 2020 | Pubmed ID: 31441378
Cardioprotective effects of idebenone do not involve ROS scavenging: Evidence for mitochondrial complex I bypass in ischemia/reperfusion injury.
Journal of molecular and cellular cardiology 10, 2019 | Pubmed ID: 31445917
Pharmacological approaches to tackle NCLs.
Biochimica et biophysica acta. Molecular basis of disease 09, 2020 | Pubmed ID: 31521819
Data on analysis of MK-801 bioavailability in mouse plasma and brain tissue by ultra-performance liquid chromatography-tandem mass spectrometry.
Data in brief Dec, 2019 | Pubmed ID: 31692721
Medicinal plants and their uses recorded in the Archives of Latvian Folklore from the 19th century.
Journal of ethnopharmacology Mar, 2020 | Pubmed ID: 31707047
Investigation of Antibacterial and Antiinflammatory Activities of Proanthocyanidins from DC Root Extract.
Nutrients Nov, 2019 | Pubmed ID: 31752295
Altered mitochondrial metabolism in the insulin-resistant heart.
Acta physiologica (Oxford, England) 03, 2020 | Pubmed ID: 31840389
Data on medicinal plants in the records of Latvian folk medicine from the 19th century.
Data in brief Feb, 2020 | Pubmed ID: 31909122
Decreases in Circulating Concentrations of Long-Chain Acylcarnitines and Free Fatty Acids During the Glucose Tolerance Test Represent Tissue-Specific Insulin Sensitivity.
Frontiers in endocrinology , 2019 | Pubmed ID: 31920980
Excretion of the Polymyxin Derivative NAB739 in Murine Urine.
Antibiotics (Basel, Switzerland) Mar, 2020 | Pubmed ID: 32230751
Neuroprotective and anti-inflammatory activity of DAT inhibitor R-phenylpiracetam in experimental models of inflammation in male mice.
Inflammopharmacology Oct, 2020 | Pubmed ID: 32279140
Safety and Tolerability of the Anxiolytic and Nootropic Drug Phenibut: A Systematic Review of Clinical Trials and Case Reports.
Pharmacopsychiatry Sep, 2020 | Pubmed ID: 32340063
Cardiac metabolism as a driver and therapeutic target of myocardial infarction.
Journal of cellular and molecular medicine 06, 2020 | Pubmed ID: 32384583
Empagliflozin Protects Cardiac Mitochondrial Fatty Acid Metabolism in a Mouse Model of Diet-Induced Lipid Overload.
Cardiovascular drugs and therapy 12, 2020 | Pubmed ID: 32424653
Low-intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults.
Physiological reports 06, 2020 | Pubmed ID: 32562386
Inhibition of sigma-1 receptors substantially modulates GABA and glutamate transport in presynaptic nerve terminals.
Experimental neurology 11, 2020 | Pubmed ID: 32795464
Metformin decreases bacterial trimethylamine production and trimethylamine N-oxide levels in db/db mice.
Scientific reports 09, 2020 | Pubmed ID: 32884086
Inhibition of CPT2 exacerbates cardiac dysfunction and inflammation in experimental endotoxaemia.
Journal of cellular and molecular medicine 10, 2020 | Pubmed ID: 32896106
Rats with congenital hydronephrosis show increased susceptibility to renal ischemia-reperfusion injury.
Physiological reports 11, 2020 | Pubmed ID: 33207081
Mitochondrial-Protective Effects of R-Phenibut after Experimental Traumatic Brain Injury.
Oxidative medicine and cellular longevity , 2020 | Pubmed ID: 33274011
Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production.
Scientific reports 12, 2020 | Pubmed ID: 33299068
Chemical composition of Prunus padus L. flower extract and its anti-inflammatory activities in primary bone marrow-derived macrophages.
Journal of ethnopharmacology Mar, 2021 | Pubmed ID: 33307057
Genetic inactivation of the sigma-1 chaperone protein results in decreased expression of the R2 subunit of the GABA-B receptor and increased susceptibility to seizures.
Neurobiology of disease 03, 2021 | Pubmed ID: 33385516
Energy substrate metabolism and mitochondrial oxidative stress in cardiac ischemia/reperfusion injury.
Free radical biology & medicine 03, 2021 | Pubmed ID: 33484825
Microbiota-Derived Metabolite Trimethylamine N-Oxide Protects Mitochondrial Energy Metabolism and Cardiac Functionality in a Rat Model of Right Ventricle Heart Failure.
Frontiers in cell and developmental biology , 2020 | Pubmed ID: 33520996
Long-Chain Acylcarnitines Decrease the Phosphorylation of the Insulin Receptor at Tyr1151 Through a PTP1B-Dependent Mechanism.
International journal of molecular sciences Jun, 2021 | Pubmed ID: 34208786
Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats.
Oxidative medicine and cellular longevity , 2021 | Pubmed ID: 34367467
The Cultivation of L. Increased the Total Alkaloid Content and Cytotoxic Activity Compared with Those of Wild-Grown Plants.
Plants (Basel, Switzerland) Sep, 2021 | Pubmed ID: 34579502
Low cardiac content of long-chain acylcarnitines in TMLHE knockout mice prevents ischaemia-reperfusion-induced mitochondrial and cardiac damage.
Free radical biology & medicine 12, 2021 | Pubmed ID: 34728372
Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury.
International journal of molecular sciences Oct, 2021 | Pubmed ID: 34769042
Assessment of Iodine and Selenium Nutritional Status in Women of Reproductive Age in Latvia.
Medicina (Kaunas, Lithuania) Nov, 2021 | Pubmed ID: 34833429
HMDB 5.0: the Human Metabolome Database for 2022.
Nucleic acids research Jan, 2022 | Pubmed ID: 34986597
Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19.
International journal of molecular sciences Dec, 2021 | Pubmed ID: 35008470
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