Laboratory of Pharmaceutical Pharmacology
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Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart.
Life sciences Oct, 2008 | Pubmed ID: 18801379
Myocardial infarct size-limiting and anti-arrhythmic effects of mildronate orotate in the rat heart.
Cardiovascular drugs and therapy Aug, 2009 | Pubmed ID: 19536647
Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats.
British journal of pharmacology Aug, 2009 | Pubmed ID: 19594753
Effects of long-term mildronate treatment on cardiac and liver functions in rats.
Basic & clinical pharmacology & toxicology Dec, 2009 | Pubmed ID: 19663820
Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism.
Journal of enzyme inhibition and medicinal chemistry Dec, 2009 | Pubmed ID: 19912061
Mildronate treatment alters γ-butyrobetaine and l-carnitine concentrations in healthy volunteers.
The Journal of pharmacy and pharmacology Sep, 2011 | Pubmed ID: 21827492
Administration of L-carnitine and mildronate improves endothelial function and decreases mortality in hypertensive Dahl rats.
Pharmacological reports : PR , 2011 | Pubmed ID: 21857086
The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine.
Journal of cardiovascular pharmacology and therapeutics Jun, 2012 | Pubmed ID: 21903968
A short-term high-dose administration of sodium pivalate impairs pyruvate metabolism without affecting cardiac function.
Cardiovascular toxicology Dec, 2012 | Pubmed ID: 22539084
Troubleshooting digital macro photography for image acquisition and the analysis of biological samples.
Journal of pharmacological and toxicological methods Mar-Apr, 2013 | Pubmed ID: 23202591
Activated peroxisomal fatty acid metabolism improves cardiac recovery in ischemia-reperfusion.
Naunyn-Schmiedeberg's archives of pharmacology Jun, 2013 | Pubmed ID: 23525500
The heart is better protected against myocardial infarction in the fed state compared to the fasted state.
Metabolism: clinical and experimental Jan, 2014 | Pubmed ID: 24140100
Magnesium nitrate attenuates blood pressure rise in SHR rats.
Magnesium research Jan-Mar, 2014 | Pubmed ID: 24827813
Selective inhibition of OCTN2 is more effective than inhibition of gamma-butyrobetaine dioxygenase to decrease the availability of l-carnitine and to reduce myocardial infarct size.
Pharmacological research Jul, 2014 | Pubmed ID: 24836867
Long-chain acylcarnitine content determines the pattern of energy metabolism in cardiac mitochondria.
Molecular and cellular biochemistry Oct, 2014 | Pubmed ID: 24878991
Expression and purification of active, stabilized trimethyllysine hydroxylase.
Protein expression and purification 12, 2014 | Pubmed ID: 25220864
Suppression of intestinal microbiota-dependent production of pro-atherogenic trimethylamine N-oxide by shifting L-carnitine microbial degradation.
Life sciences Nov, 2014 | Pubmed ID: 25301199
Methyl-γ-butyrobetaine decreases levels of acylcarnitines and attenuates the development of atherosclerosis.
Vascular pharmacology Sep, 2015 | Pubmed ID: 25989106
Structure and Function of CutC Choline Lyase from Human Microbiota Bacterium Klebsiella pneumoniae.
The Journal of biological chemistry Aug, 2015 | Pubmed ID: 26187464
Decreased acylcarnitine content improves insulin sensitivity in experimental mice models of insulin resistance.
Pharmacological research 11, 2016 | Pubmed ID: 26621248
Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity.
Pharmacological research 11, 2016 | Pubmed ID: 26850121
Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria.
The Biochemical journal 05, 2016 | Pubmed ID: 26936967
Decrease in Long-Chain Acylcarnitine Tissue Content Determines the Duration of and Correlates with the Cardioprotective Effect of Methyl-GBB.
Basic & clinical pharmacology & toxicology Aug, 2017 | Pubmed ID: 28244203
Acute and long-term administration of palmitoylcarnitine induces muscle-specific insulin resistance in mice.
BioFactors (Oxford, England) Sep, 2017 | Pubmed ID: 28759135
Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues.
Scientific reports 12, 2017 | Pubmed ID: 29235526
Skull Fractures Induce Neuroinflammation and Worsen Outcomes after Closed Head Injury in Mice.
Journal of neurotrauma 01, 2020 | Pubmed ID: 31441378
Excretion of the Polymyxin Derivative NAB739 in Murine Urine.
Antibiotics (Basel, Switzerland) Mar, 2020 | Pubmed ID: 32230751
Empagliflozin Protects Cardiac Mitochondrial Fatty Acid Metabolism in a Mouse Model of Diet-Induced Lipid Overload.
Cardiovascular drugs and therapy 12, 2020 | Pubmed ID: 32424653
Metformin decreases bacterial trimethylamine production and trimethylamine N-oxide levels in db/db mice.
Scientific reports 09, 2020 | Pubmed ID: 32884086
Inhibition of CPT2 exacerbates cardiac dysfunction and inflammation in experimental endotoxaemia.
Journal of cellular and molecular medicine 10, 2020 | Pubmed ID: 32896106
-Fluorine Effect in Cyclopropane: Diastereoselective Synthesis of Fluorocyclopropyl Cabozantinib Analogs.
ACS medicinal chemistry letters Nov, 2020 | Pubmed ID: 33214822
Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and Protects against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats.
Oxidative medicine and cellular longevity , 2021 | Pubmed ID: 34367467
Low cardiac content of long-chain acylcarnitines in TMLHE knockout mice prevents ischaemia-reperfusion-induced mitochondrial and cardiac damage.
Free radical biology & medicine 12, 2021 | Pubmed ID: 34728372
Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis.
EBioMedicine Nov, 2021 | Pubmed ID: 34740109
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors.
Nature chemistry Jan, 2022 | Pubmed ID: 34903857
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