Darrell Kotton

Pulmonary Center, Boston University School of Medicine

Affiliated withBoston University School of Medicine Boston University and Boston Medical Center

Research Area

Developmental Biology

Biography

JoVE Journal Publications

Article Total : 1	Year
Publication title	2022

Other Publications

Article	Year
Stem cell antigen-1 expression in the pulmonary vascular endothelium. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 12611818	2003
Side population cells and Bcrp1 expression in lung. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 12626330	2003
Lung stem cells: new paradigms. Experimental hematology\| PubMed ID: 15050743	2004
Embryonic lung side population cells are hematopoietic and vascular precursors. American journal of respiratory cell and molecular biology\| PubMed ID: 15802552	2005
A novel stem-cell population in adult liver with potent hematopoietic-reconstitution activity. Blood\| PubMed ID: 15870171	2005
Failure of bone marrow to reconstitute lung epithelium. American journal of respiratory cell and molecular biology\| PubMed ID: 15961722	2005
Lung stem cells. Cell and tissue research\| PubMed ID: 17805578	2008
The prolonged life-span of alveolar macrophages. American journal of respiratory cell and molecular biology\| PubMed ID: 18192503	2008
Another notch in stem cell biology: Drosophila intestinal stem cells and the specification of cell fates. BioEssays : news and reviews in molecular, cellular and developmental biology\| PubMed ID: 18200564	2008
Sustained expression of alpha1-antitrypsin after transplantation of manipulated hematopoietic stem cells. American journal of respiratory cell and molecular biology\| PubMed ID: 18323534	2008
Induced pluripotent stem cell generation using a single lentiviral stem cell cassette. Stem cells (Dayton, Ohio)\| PubMed ID: 19096035	2009
Transcriptional analysis of fracture healing and the induction of embryonic stem cell-related genes. PloS one\| PubMed ID: 19415118	2009
Pulmonary alveolar proteinosis: a bench-to-bedside story of granulocyte-macrophage colony-stimulating factor dysfunction. Chest\| PubMed ID: 19666756	2009
Excision of reprogramming transgenes improves the differentiation potential of iPS cells generated with a single excisable vector. Stem cells (Dayton, Ohio)\| PubMed ID: 19904830	2010
Epigenetic mechanisms modulate thyroid transcription factor 1-mediated transcription of the surfactant protein B gene. The Journal of biological chemistry\| PubMed ID: 19906647	2010
Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages. The Journal of clinical investigation\| PubMed ID: 20038801	2010
miR-129 regulates cell proliferation by downregulating Cdk6 expression. Cell cycle (Georgetown, Tex.)\| PubMed ID: 20404570	2010
FOXO1 modulates osteoblast differentiation. Bone\| PubMed ID: 21281751	2011
Telomere dysfunction induces metabolic and mitochondrial compromise. Nature\| PubMed ID: 21307849	2011
Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes. The Journal of clinical investigation\| PubMed ID: 21537085	2011
A shift from cell cultures to creatures: in vivo imaging of small animals in experimental regenerative medicine. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 21952170	2011
Programmatic change: lung disease research in the era of induced pluripotency. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 21984571	2011
Role of Nanog in the maintenance of marrow stromal stem cells during post natal bone regeneration. Biochemical and biophysical research communications\| PubMed ID: 22142851	2012
Maintenance and repair of the lung endothelium does not involve contributions from marrow-derived endothelial precursor cells. American journal of respiratory cell and molecular biology\| PubMed ID: 22323363	2012
Self-renewing endodermal progenitor lines generated from human pluripotent stem cells. Cell stem cell\| PubMed ID: 22482503	2012
Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell stem cell\| PubMed ID: 22482505	2012
Next-generation regeneration: the hope and hype of lung stem cell research. American journal of respiratory and critical care medicine\| PubMed ID: 22517787	2012
The Transcription Factors Grainyhead-like 2 and NK2-Homeobox 1 Form a Regulatory Loop That Coordinates Lung Epithelial Cell Morphogenesis and Differentiation. The Journal of biological chemistry\| PubMed ID: 22955271	2012
The 2012 Nobel Prize in physiology or medicine: democratizing pluripotency for lung researchers. American journal of respiratory and critical care medicine\| PubMed ID: 23204376	2012
Residual expression of reprogramming factors affects the transcriptional program and epigenetic signatures of induced pluripotent stem cells. PloS one\| PubMed ID: 23272148	2012
Lentiviral delivery of RNAi for in vivo lineage-specific modulation of gene expression in mouse lung macrophages. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 23403494	2013
Intracellular bacillary burden reflects a burst size for Mycobacterium tuberculosis in vivo. PLoS pathogens\| PubMed ID: 23436998	2013
Lectin-dependent enhancement of Ebola virus infection via soluble and transmembrane C-type lectin receptors. PloS one\| PubMed ID: 23573288	2013
The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation. Blood\| PubMed ID: 23723449	2013
Diffuse lung disease in children: summary of a scientific conference. Pediatric pulmonology\| PubMed ID: 23798474	2014
Diminished Memory T-Cell Expansion Due to Delayed Kinetics of Antigen Expression by Lentivectors. PloS one\| PubMed ID: 23824049	2013
Clonal genetic and hematopoietic heterogeneity among human-induced pluripotent stem cell lines. Blood\| PubMed ID: 23940280	2013
Induced pluripotent stem cell modeling of multisystemic, hereditary transthyretin amyloidosis. Stem cell reports\| PubMed ID: 24286032	2013
Modeling pulmonary alveolar proteinosis with induced pluripotent stem cells. American journal of respiratory and critical care medicine\| PubMed ID: 24428646	2014
Derivation of Endodermal Progenitors From Pluripotent Stem Cells. Journal of cellular physiology\| PubMed ID: 25160562	2015
Induced pluripotent stem cells model personalized variations in liver disease resulting from α1-antitrypsin deficiency. Hepatology (Baltimore, Md.)\| PubMed ID: 25690322	2015
Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells. Stem cell reports\| PubMed ID: 25843048	2015
Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells. Cell stem cell\| PubMed ID: 26593959	2015
Unstable neurons underlie a stable learned behavior. Nature neuroscience\| PubMed ID: 27723744	2016
Thyroid Progenitors Are Robustly Derived from Embryonic Stem Cells through Transient, Developmental Stage-Specific Overexpression of Nkx2-1. Stem cell reports\| PubMed ID: 28162994	2017
Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling. Cell stem cell\| PubMed ID: 28366587	2017
Capacity of Pneumococci to Activate Macrophage Nuclear Factor κB: Influence on Necroptosis and Pneumonia Severity. The Journal of infectious diseases\| PubMed ID: 28368460	2017
Prospective isolation of NKX2-1-expressing human lung progenitors derived from pluripotent stem cells. The Journal of clinical investigation\| PubMed ID: 28463226	2017
Interview with Darrell Kotton. Regenerative medicine\| PubMed ID: 28621167	2017
Pluripotent stem cell differentiation reveals distinct developmental pathways regulating lung- versus thyroid-lineage specification. Development (Cambridge, England)\| PubMed ID: 28947536	2017
Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells. Cell stem cell\| PubMed ID: 28965766	2017
Claudin-18: unexpected regulator of lung alveolar epithelial cell proliferation. The Journal of clinical investigation\| PubMed ID: 29400691	2018
Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium. Stem cell reports\| PubMed ID: 29657097	2018
Derivation of Epithelial-Only Airway Organoids from Human Pluripotent Stem Cells. Current protocols in stem cell biology\| PubMed ID: 30040246	2018
Pulmonary Ionocytes Challenge the Paradigm in Cystic Fibrosis. Trends in pharmacological sciences\| PubMed ID: 30213439	2018
Generation of a Purified iPSC-Derived Smooth Muscle-like Population for Cell Sheet Engineering. Stem cell reports\| PubMed ID: 31422908	2019
Derivation of self-renewing lung alveolar epithelial type II cells from human pluripotent stem cells. Nature protocols\| PubMed ID: 31732721	2019
Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells. Nature communications\| PubMed ID: 31924806	2020
Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows during Differentiation of Human PSC-Derived Distal Lung Progenitors. Cell stem cell\| PubMed ID: 32004478	2020
The in vivo genetic program of murine primordial lung epithelial progenitors. Nature communications\| PubMed ID: 32005814	2020
The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future. Cell stem cell\| PubMed ID: 32243808	2020
Hidden neural states underlie canary song syntax. Nature\| PubMed ID: 32555461	2020
Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factors. bioRxiv : the preprint server for biology\| PubMed ID: 32577635	2020
Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19. bioRxiv : the preprint server for biology\| PubMed ID: 32577649	2020
Differentiation of human airway-organoids from induced pluripotent stem cells (iPSCs). Methods in cell biology\| PubMed ID: 32586451	2020
A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells. Stem cell reports\| PubMed ID: 32619491	2020
Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease. Stem cell reports\| PubMed ID: 32735824	2020
Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells. Cell stem cell\| PubMed ID: 32891189	2020
SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response. Cell stem cell\| PubMed ID: 32979316	2020
Common genetic variation in humans impacts susceptibility to SARS-CoV-2 infection. bioRxiv : the preprint server for biology\| PubMed ID: 32995783	2020
Epithelial Stem and Progenitor Cells in Lung Repair and Regeneration. Annual review of physiology\| PubMed ID: 33074772	2021
Reconstructed signaling and regulatory networks identify potential drugs for SARS-CoV-2 infection. bioRxiv : the preprint server for biology\| PubMed ID: 33083801	2021
Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells. Cell stem cell\| PubMed ID: 33098807	2021
Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Molecular cell\| PubMed ID: 33259812	2020
Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection. Stem cell reports\| PubMed ID: 33636110	2021
SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 33811184	2021
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation. Science immunology\| PubMed ID: 33827897	2021
Derivation of Thyroid Follicular Cells From Pluripotent Stem Cells: Insights From Development and Implications for Regenerative Medicine. Frontiers in endocrinology\| PubMed ID: 33959101	2021
Heterogeneity in Human Induced Pluripotent Stem Cell-derived Alveolar Epithelial Type II Cells Revealed with ABCA3/SFTPC Reporters. American journal of respiratory cell and molecular biology\| PubMed ID: 34101541	2021
Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 34413211	2021
Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease. Cell reports\| PubMed ID: 34469722	2021
Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors. Nature communications\| PubMed ID: 34789735	2021
Gaining Insight into Mitochondrial Genetic Variation and Downstream Pathophysiology: What Can i(PSCs) Do? Genes\| PubMed ID: 34828274	2021
Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5 basal cells. Nature cell biology\| PubMed ID: 34969962	2022
Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 35020534	2022
Recombinant Lloviu virus as a tool to study viral replication and host responses. PLoS pathogens\| PubMed ID: 35120176	2022
Epithelial LIF signaling limits apoptosis and lung injury during bacterial pneumonia. American journal of physiology. Lung cellular and molecular physiology\| PubMed ID: 35137631	2022
CoSpar identifies early cell fate biases from single-cell transcriptomic and lineage information. Nature biotechnology\| PubMed ID: 35190690	2022
Editorial: Progenitors and Stem Cells in Thyroid Development, Disease, and Regeneration. Frontiers in endocrinology\| PubMed ID: 35211095	2022
Specific mesoderm subset derived from human pluripotent stem cells ameliorates microvascular pathology in type 2 diabetic mice. Science advances\| PubMed ID: 35245116	2022
Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell-derived alveolar epithelium. JCI insight\| PubMed ID: 35315362	2022