Joshua D. Webster

Department of Pathology, Genentech

Affiliated withGenentech

Research Area

Biology

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2022

Other Publications

Article	Year
Whole-slide imaging and automated image analysis: considerations and opportunities in the practice of pathology. Veterinary pathology\| PubMed ID: 24091812	2014
Regulation of proximal T cell receptor signaling and tolerance induction by deubiquitinase Usp9X. The Journal of experimental medicine\| PubMed ID: 25200027	2014
Immunohistochemical detection of FLAG-tagged endogenous proteins in knock-in mice. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society\| PubMed ID: 25575566	2015
Small molecule kinase inhibitors in veterinary oncology. Veterinary journal (London, England : 1997)\| PubMed ID: 25744806	2015
β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1. Cell\| PubMed ID: 26627735	2015
Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response. Science signaling\| PubMed ID: 26628680	2015
NeuCode Proteomics Reveals Bap1 Regulation of Metabolism. Cell reports\| PubMed ID: 27373151	2016
Transcriptional profiling of canine mast cell tumors: Searching for candidate targets and prognostic markers. Veterinary journal (London, England : 1997)\| PubMed ID: 27387731	2016
Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death. Cell death and differentiation\| PubMed ID: 27518435	2017
RIPK1 inhibits ZBP1-driven necroptosis during development. Nature\| PubMed ID: 27819682	2016
Multifaceted Roles of Autophagy in Health and Disease. Veterinary pathology\| PubMed ID: 29635994	2018
OTULIN limits cell death and inflammation by deubiquitinating LUBAC. Nature\| PubMed ID: 29950720	2018
Observational Study Design in Veterinary Pathology, Part 1: Study Design. Veterinary pathology\| PubMed ID: 30071806	2018
Kinase domain dimerization drives RIPK3-dependent necroptosis. Science signaling\| PubMed ID: 30131368	2018
Detection of Necroptosis by Phospho-RIPK3 Immunohistochemical Labeling. Methods in molecular biology (Clifton, N.J.)\| PubMed ID: 30136239	2018
The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma. Pigment cell & melanoma research\| PubMed ID: 30156010	2019
The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors. Science signaling\| PubMed ID: 30206136	2018
Observational Study Design in Veterinary Pathology, Part 2: Methodology. Veterinary pathology\| PubMed ID: 30227783	2018
Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 30322923	2018
The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification. PloS one\| PubMed ID: 30951545	2019
Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1. Science (New York, N.Y.)\| PubMed ID: 31000662	2019
RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases. Cell death and differentiation\| PubMed ID: 31101885	2020
Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation. Cell reports\| PubMed ID: 31141691	2019
Prognostic and predictive significance of KIT protein expression and c-kit gene mutation in canine cutaneous mast cell tumours: A consensus of the Oncology-Pathology Working Group. Veterinary and comparative oncology\| PubMed ID: 31264352	2019
Unobstructed Multiscale Imaging of Tissue Sections for Ultrastructural Pathology Analysis by Backscattered Electron Scanning Microscopy. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society\| PubMed ID: 31385742	2020
Applications and considerations for the use of genetically engineered mouse models in drug development. Cell and tissue research\| PubMed ID: 31486957	2020
Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis. Nature\| PubMed ID: 31511692	2019
The RIPK4-IRF6 signalling axis safeguards epidermal differentiation and barrier function. Nature\| PubMed ID: 31578523	2019
Activity of caspase-8 determines plasticity between cell death pathways. Nature\| PubMed ID: 31723262	2019
RIP1 kinase activity is critical for skin inflammation but not for viral propagation. Journal of leukocyte biology\| PubMed ID: 31985117	2020
The Tumor Suppressor BAP1 Regulates the Hippo Pathway in Pancreatic Ductal Adenocarcinoma. Cancer research\| PubMed ID: 31988076	2020
MAP4K4 negatively regulates CD8 T cell-mediated antitumor and antiviral immunity. Science immunology\| PubMed ID: 32220977	2020
Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury. Journal of the American Society of Nephrology : JASN\| PubMed ID: 32651223	2020
The Balance of TNF Mediated Pathways Regulates Inflammatory Cell Death Signaling in Healthy and Diseased Tissues. Frontiers in cell and developmental biology\| PubMed ID: 32671059	2020
Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia. Cell\| PubMed ID: 32795415	2020
Integration of innate immune signalling by caspase-8 cleavage of N4BP1. Nature\| PubMed ID: 32971525	2020
Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS. Cell death and differentiation\| PubMed ID: 32994544	2021
Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death. Cell death and differentiation\| PubMed ID: 32999468	2021
NINJ1 mediates plasma membrane rupture during lytic cell death. Nature\| PubMed ID: 33472215	2021
Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injury. Cell death & disease\| PubMed ID: 33828080	2021
Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection. Cell host & microbe\| PubMed ID: 34492225	2021
Reporting guidelines for manuscripts on tumor prognosis. Veterinary pathology\| PubMed ID: 35220838	2022