Joshua D. Webster

Whole-slide imaging and automated image analysis: considerations and opportunities in the practice of pathology.

Regulation of proximal T cell receptor signaling and tolerance induction by deubiquitinase Usp9X.

Immunohistochemical detection of FLAG-tagged endogenous proteins in knock-in mice.

Small molecule kinase inhibitors in veterinary oncology.

β-Cell Insulin Secretion Requires the Ubiquitin Ligase COP1.

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.

NeuCode Proteomics Reveals Bap1 Regulation of Metabolism.

Transcriptional profiling of canine mast cell tumors: Searching for candidate targets and prognostic markers.

Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death.

RIPK1 inhibits ZBP1-driven necroptosis during development.

Multifaceted Roles of Autophagy in Health and Disease.

OTULIN limits cell death and inflammation by deubiquitinating LUBAC.

Observational Study Design in Veterinary Pathology, Part 1: Study Design.

Kinase domain dimerization drives RIPK3-dependent necroptosis.

Detection of Necroptosis by Phospho-RIPK3 Immunohistochemical Labeling.

The tumor suppressor BAP1 cooperates with BRAFV600E to promote tumor formation in cutaneous melanoma.

The Hippo pathway effector TAZ induces TEAD-dependent liver inflammation and tumors.

Observational Study Design in Veterinary Pathology, Part 2: Methodology.

Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain.

The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification.

Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1.

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases.

Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation.

Prognostic and predictive significance of KIT protein expression and c-kit gene mutation in canine cutaneous mast cell tumours: A consensus of the Oncology-Pathology Working Group.

Unobstructed Multiscale Imaging of Tissue Sections for Ultrastructural Pathology Analysis by Backscattered Electron Scanning Microscopy.

Applications and considerations for the use of genetically engineered mouse models in drug development.

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis.

The RIPK4-IRF6 signalling axis safeguards epidermal differentiation and barrier function.

Activity of caspase-8 determines plasticity between cell death pathways.

RIP1 kinase activity is critical for skin inflammation but not for viral propagation.

The Tumor Suppressor BAP1 Regulates the Hippo Pathway in Pancreatic Ductal Adenocarcinoma.

MAP4K4 negatively regulates CD8 T cell-mediated antitumor and antiviral immunity.

Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury.

The Balance of TNF Mediated Pathways Regulates Inflammatory Cell Death Signaling in Healthy and Diseased Tissues.

Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia.

Integration of innate immune signalling by caspase-8 cleavage of N4BP1.

Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS.

Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death.

NINJ1 mediates plasma membrane rupture during lytic cell death.

Genetic inactivation of RIP1 kinase activity in rats protects against ischemic brain injury.

Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection.

Reporting guidelines for manuscripts on tumor prognosis.